高危患者术后TNF-α及IL-6水平变化与感染性并发症及MODS关系的研究  

Changes in Serum Levels of TNF-α and IL-6 and Relationship with Multiple Organ Dysfunction Syndrome after Thoracic Operation

作　　者：黄志勇[1] 张军[1] 

机构地区：[1]广州市南方医科大学南方医院,广东广州510515

出　　处：《中华医院感染学杂志》2007年第5期486-487,共2页Chinese Journal of Nosocomiology

基　　金：广东卫生厅基金资助(A2002393)

摘　　要：目的研究高危患者开胸术后血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)水平的变化,了解其与感染性并发症及多脏器功能不全综合征(MODS)的关系,探讨MODS发生的预后因素。方法选择2000-2003年间46例高危良性疾病患者,动态观察术后当日、第3、7、14、21天血清TNF-α、IL-6及血像的变化,并按是否发生MODS分成两组,比较MODS的发生率及其相关性。结果46例手术患者发生感染者占83%,重度感染占42%,两周内发生MODS者7例,MODS组血清TNF-αI、L-6水平均较非MODS组明显升高,TNF-α含量的变化与MODS发生的相关性系数r=0.9145,IL-6为0.8832。结论开胸术后血清TNF-α及IL-6水平的升高是MODS发生的重要预后因素,其升高程度与MODS的发生呈正相关。OBJECTIVE To evaluate the changes in serum levels of TNF-α and IL-6 after thoracic operation, and the relationship with multiple organ dysfunction syndrome （MODS）. METHODS Serum levels of TNF-αand IL-6 in 46 cases of benign disease Between 2000 to 2003 were observed on the day of operation, the 3rd, 7th, 14th and 21th days after operation, the patients were divided into two groups according to the presence of MODS. RESULTS Cases occurred MODS in two weeks after thoracic operation, the serum levels of TNF-α and IL-6 were markedly higher in MODS than that in non-MODS, the correlation coefficients between them were r= 0. 9145, P〈0.01, and r=0. 8832, P〈0. 01. CONCLUSIONS The increase in TNF-α and IL-6 levels might be served as effective markers and closely related with MODS.

关 键 词：手术 肿瘤坏死因子Α 白介素6 多脏器功能不全综合征 

分 类 号：R442.2[医药卫生—诊断学]