高渗盐水对慢性鼻窦炎患者鼻腔黏膜纤毛清除功能的影响  

Effect of hypertonic saline on mucociliary clearance in patients with chronic rhinosinusitis

作　　者：王德辉[1] 孙琼[1] 王锋[1] 于华鹏[1] 胡利[1] 臧朝平[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院耳鼻咽喉科,上海200031

出　　处：《山东大学耳鼻喉眼学报》2007年第2期111-112,117,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的:探讨高渗盐水对成年慢性鼻窦炎患者鼻腔黏膜纤毛运动功能的影响。方法:选取住院待行鼻内窥镜下慢性鼻窦炎手术的患者为研究对象,用鼻腔黏膜纤毛清除功能糖精清除率法检测正常状态、鼻腔生理盐水喷雾和高渗盐水喷雾后糖精清除时间,统计学方法采用Wilcoxon检验。结果:慢性鼻窦炎患者平均糖精清除时间为19.62 min,生理盐水和高渗盐水冲洗后患者平均糖精清除时间分别为17.74 min和13.22 min。与冲洗前相比,生理盐水未明显加快糖精清除速度(P>0.05),而高渗盐水冲洗后患者平均糖精清除时间明显缩短(P<0.01),平均缩短6.4 min。结论:高渗盐水可使慢性鼻窦炎患者的黏膜清除时间缩短,促进黏膜的清除功能。等渗生理盐水对黏膜清除时间影响不明显。Objective： To explore the effect of hypertonic saline on nasal muceciliary clearance in patients with chronic rhinosinusitis. Methods： The saccharin test was used to determine the mucociliary clearance before irrigation and after normal saline or hypertonic saline irrigation. On the following days, an alternative solution was used to repeat the treatment and retest the mucociliary clearance time. Results： The normal saccharin clearance time of patients with chronic rhinosinusitis was 19.62 minutes, and it changed to 17.74 and 13.22 minutes after the normal saline and hypertonic saline irrigation, respectively. Compared with the normal group, the mucociliary clearance was not significantly changed in the normal saline group （ P 〉 0.05 ）, but significantly decreased in the hypertonic saline group （ P 〈 0.01）. Condusion： Hypertonic saline can significantly improve the nasal mucociliary clearance time, while normal saline has no such effect.

关 键 词：高渗盐水 糖精清除试验 鼻窦炎 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]