幽门螺杆菌感染与胃癌关系的Meta-analysis研究  

A Meta-analysis between the helicobacter pylori infection and gastric carcinoma

作　　者：安宁[1] 李登新[2] 陈彤[3] 张建业[4] 

机构地区：[1]济南市卫生局卫生监督所,山东济南250011 [2]潍坊市人民医院消化内科,山东潍坊262200 [3]济南市中医医院针灸科,山东济南250002 [4]山东大学医学院免疫学教研室,山东济南250012

出　　处：《山东大学学报（医学版）》2007年第4期423-426,429,共5页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨幽门螺杆菌(Hp)感染胃粘膜与胃癌的关系。方法:根据资料一致性检验结果,采用随机效应模型(D-L法)对检索到的国内23篇有关流行病学研究文献进行了综合定量分析。结果:Hp感染与胃癌的发生有明显的联系(OR=2.72,95%CI:1.91-3.87);其中与胃非贲门部癌、腺癌的联系具有统计学意义,其合并OR(95%CI)依次为2.72(1.91-3.87)、3.94(2.41-6.42);与胃贲门部癌及非腺癌的联系无统计学意义(OR=1.38,95%CI:0.91-2.08)、(OR=1.55,95%CI:0.99-2.44)。结论:Hp感染与胃癌的发生有联系。文中对该综合分析结果及可能出现的偏倚进行了讨论。Objective： To investigate the correlation between Helicobacter pylori infection and gastric carcinoma. Methods： According to the consistency of the test results, twenty-three articles that referred to epidemiology were analyzed by the D-L method. Results： There was a significant correlation between gastric carcinoma and Helicobacter pylori infection（ OR = 2.72, 95%CI： 1.91 - 3.87）. There was a statistical significance between Helicobacter pylori infection with gland carcinoma and gastric non-cardia carcinoma（ OR = 2.72,3.94）, and no statistical significance between Helicobacter pylori infection with non-gland carcinoma and gastric cardia carcinoma（ OR = 1.55）. Conclusion： There is significant correlation between gastric carcinoma and Helicobacter pylori infection.

关 键 词：螺杆菌 幽门 胃癌 Meta—analysis 

分 类 号：R181.23[医药卫生—流行病学]