肺栓塞与血小板活化标志物  

Correlation between pulmonary thromboembolism and platelet activation

作　　者：蒋玲[1] 任英[1] 罗翠花[1] 

机构地区：[1]广东省深圳市宝安区西乡人民医院内科,518102

出　　处：《临床肺科杂志》2007年第7期691-692,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨肺栓塞与血小板活化的关系,以发现更加简便、可靠的检测血小板活化的方法。方法用酶联免疫吸附法测定血浆中可溶性P-选择素(PS);流式细胞术检测血小板膜上活化标记物P-选择素(CD62p)。结果PTE患者血小板膜上P-选择素及血浆中可溶性P-选择素均明显高于高危人群及正常对照组(P<0.01);高危人群血小板膜上P-选择素及血浆中可溶性P-选择素高于正常对照组;栓塞面积越大血小板膜上P-选择素及血浆中可溶性P-选择素越高,血小板的活化程度越高;说明血小板活化在肺栓塞的发病中起重要作用。结论PTE时,血浆P-选择素水平明显增高,参与了PTE的发生、发展。通过早期监测高危人群血浆P-选择素,对于预防肺栓塞有一定帮助。P-选择素可以作血栓性疾病的导向诊断和治疗提供崭新的途径。P-选择素简单、易测,上述两种方法均可作为常规检查的指标。Objective To observe the correlation between pulmonary thromboembolism and platelet activation. Methods We divided the patients into three groups ： normal control group, high risk group and PTE group （ including large scale PTE and non - large scale group）. PS （ELISA） and CD62P （ flow cytometry） were used to determine the degree of platelet activation. Results The level of CD62P on platelet membrane and soluble PS in blood plasma in the PTE patients were much higher than those in the normal control group and in the high risk group （P 〈0. 01 ）. The level of CD62P and PS in the large scale PTE patients were much higher than those in the non-large scale PTE patients （ P 〈 0.01 ）. Conclusion The level of platelet activation is much higher in patients with PTE than that in the normal control group and in the high risk group. The larger the area of embolism is, the higher the level of platelet activation is. The platelet activation may play an important role in the pathogenesis and progress of PTE.

关 键 词：血小板活化 肺栓塞 血小板膜表面P-选择素(CD62p) 血浆中可溶性P-选择素(PS) 

分 类 号：R563.5[医药卫生—呼吸系统]