双官能化的L-脯氨酰胺催化不对称直接Aldol反应  

Bifunctional L-Prolinamide Catalyzed Asymmetric Direct Aldol Reaction

作　　者：郭川胜[1] 刘全忠[1] 王雪莲[1] 何龙[1] 王振雷[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637002

出　　处：《西华师范大学学报（自然科学版）》2007年第2期172-176,共5页Journal of China West Normal University(Natural Sciences)

摘　　要：Boc保护的L-脯氨酸与光学活性联二萘酚衍生的胺类化合物反应,经过脱去Boc保护基和甲基制得了四个脯氨酰胺类化合物.考察了其不对称催化直接Aldol反应性能,构型匹配的催化剂得到相对较高的对映选择性.催化丙酮和对硝基苯甲醛的反应,最高得到了57%的产率和40%的对映体过量.Four prolinamides were prepared by the condensation of the Boc protected L-proline with amides derived from optically pure 1, 1＇- binaphthy-2, 2＇-diol, and then submission of deprotection of Boc and methyl group. Their catalytic performance in direct Aldol reaction was also examined as well. The reaction of acetone with p-nitrobenzaldehyde provided up to 57 % yield and up to 40 % ee.

关 键 词：双官能化 脯氨酰胺类化合物 不对称催化 直接ALDOL反应 

分 类 号：O626.1[理学—有机化学]