MAPK在疾病与组织损伤中的作用  

The roles of MAPK in tissue lesion and disease

作　　者：张建军[1] 官大威[1] 赵锐[1] 韩阳[1] 侯震寰[1] 杨大利[1] 

机构地区：[1]中国医科大学法医学院法医病理教研室,辽宁沈阳110001

出　　处：《中国法医学杂志》2007年第2期103-105,共3页Chinese Journal of Forensic Medicine

基　　金：国家自然科学基金资助项目(30271347);教育部留学归国基金资助项目(教外留司[2002]367)

摘　　要：丝裂酶原活化蛋白激酶(MAPK)是生物体内重要的信号转导系统之一。MAPK信号转导通路中3组分激活模件内的激酶,引发一系列的磷酸化级联反应,参与细胞的生长、发育、分裂、分化、死亡以及细胞间的功能等多种细胞过程。本文就MAPK信号转导通路的组成成分、调控方式和作用机制的研究现状作一综述,旨在为组织损伤程度和伤后时间推断的法医学研究提供参考资料。Mitogen-activated protein kinase（MAPK） is one of the important signal transduction systems in organism. The three-component module of MAPK, in which the protein kinases activate a successive phosphorylation cascade, is involved in many cellular processes, such as cell growth, development, division, differentiation, death and coordination of cellular processes. The components, regulation mode and mechanisms involved in the MAPK pathway are reviewed in the article, which may provide understanding for estimatiion of the degree of tissue lesion and wound age in forensic research.

关 键 词：法医病理学 丝裂酶原活化蛋白激酶(MAPKs) 信号转导通路 疾病和损伤 

分 类 号：D919[医药卫生—法医学]