Homer蛋白的研究进展及法医学应用  

Advancement in the study on Homer proteins end their applicability to forensic medicine

作　　者：亢登峰[1] 王英元[1] 李晓英[2] 

机构地区：[1]山西医科大学法医学院,山西太原030001 [2]山西医科大学第一医院心内科,山西太原030001

出　　处：《中国法医学杂志》2007年第2期105-107,共3页Chinese Journal of Forensic Medicine

摘　　要：Homer蛋白由Homer 1～3基因编码,属于新发现的突触后密度蛋白家族成员,其所有剪切变异体可分为长、短两种亚型,在调控兴奋性突触的结构和功能及细胞内信号转导中发挥关键作用。作为即早基因表达产物的短亚型Homer la,在癫痫、高频刺激及发育过程中可通过海马或皮层神经元的兴奋性突触活动,快速短暂地诱导其表达增加。大鼠弥漫性脑损伤后可诱导大脑皮层神经元Homer la表达动态上调。本文简述其结构、分布、功能、研究进展、存在问题及其在法医学上的应用。The Homer proteins, encoded by three genes （Homer 1 ～3）, belong to one of the newly found postsynaptic density protein families, and several different splice variants of the Homer gene have been identified recently. This family is composed of two major groups, the short-form proteins and the long-form proteins. Homer proteins play a pivotal role in regulating the structure and function of excitatory synapses and cellular signal transduction. As an immediately early gene, Homer 1 a is induced to be expressed transiently in neurons of the hippocampus and cortex by excitatory synaptic activity following seizure, high frequency stimulation,or during development. A diffuse traumatic brain injury can up-ragulate dynamically the Homer 1 a gene expression in cortical neurons in rats. The paper summarizes the structure, distribution and function of Homer proteins, issues remained and advancements in research as well as its possible applicability in forensic medicine.

关 键 词：法医病理学 损伤时间推断 Homer蛋白 脑损伤 可卡因 

分 类 号：D919[医药卫生—法医学]