铜锌等过渡金属离子与Aβ肽作用研究进展  

Progress in Interactions of Transition Metal ions such as Copper and Zinc with β-Amyloid Peptide Associated with Alzheimer's Disease

作　　者：张志刚[1] 马旭艳[1] 

机构地区：[1]山西大学分子科学研究所化学生物学与分子工程教育部重点实验室,山西太原030006

出　　处：《山西大学学报（自然科学版）》2007年第1期83-87,共5页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金(30470408)

摘　　要：老年痴呆症的一个主要病理学特征是脑部出现淀粉样沉积,其主要成分是由40-42个氨基酸残基组成的淀粉样β多肽（Amyloidβ- peptide,简称Aβ）.铜锌等过渡金属离子与Aβ肽的沉积直接相关,研究这些金属离子与Aβ肽的作用对理解老年痴呆症的病理过程并开发相应的治疗药物至关重要.文章综述了过渡金属离子Cu、Zn和Fe与Aβ肽作用的研究进展.Alzheimer＇s disease （AD） is characterized pathologically by the deposition of amyloid,the major component of which is a 40-42 residue peptide known as the β-amyloid peptide （Aβ）. Metal ions such as Zn and Cu are implicated in aggregation of Aβ. Studying the interactions of these metals ions with Aβ is very important for us to understand the pathogenesis of AD and develop new therapeutic agents. The study on interactions of transition metal ions such as Zn,Cu and Fe with Aβ was reviewed.

关 键 词：老年痴呆症 Aβ肽 铜离子 铁离子 锌离子 

分 类 号：O627[理学—有机化学] R749.053[理学—化学]