n-HA/PA66复合生物活性支撑材料在重建椎体结构中的初步临床应用  

Initial clinical research of biomimetic and supportive n-HA/PA66 composites for structural reconstruction of vertebral body in spine

作　　者：蒋电明[1] 权正学[1] 欧云生[1] 倪卫东[1] 梁熙[1] 

机构地区：[1]重庆医科大学附属第一医院骨科,重庆市脊柱外科中心,400016

出　　处：《重庆医学》2007年第11期1010-1012,共3页Chongqing medicine

基　　金：国家高新技术研究发展"863"计划资助项目(2002AA326020)

摘　　要：目的探讨自行研制的纳米羟基磷灰石/聚酰胺66（n-HA/PA66）复合生物活性支撑材料在恢复椎体结构和高度中的作用。方法从2003年12月-2005年5月行n-HA/PA66复合生物活性支撑材料移植重建脊柱前路手术后的椎体缺损共36例。应用病种：椎体爆裂骨折32例、原发椎间隙感染2例、椎体肿瘤2例。结果随访6-21个月（平均8个月）,影像学资料显示植入体3-4个月与上下相邻椎体愈合、重建的椎体高度没有降低、术前神经损伤不同程度恢复。结论纳米羟基类磷灰石/聚酰胺66（n-HA/PA66）复合生物活性支撑材料可有效恢复椎体高度和结构,并能与椎体愈合,达到有效重建椎体结构的作用,可以临床推广使用。Objective To study the clinical effects of the biomimetic and supportive n-HA/PA66 composites for the structural reconstruction and height restoring of vertebral body in the thoracolumbar spine. Methods Thirty-six patients received operation to reconstruct the spinal vertebral structure with the biomimetic and supportive n-HA/PA66 composites from anterior approach because of the vertebral deficit. There were 32 cases of vertebral bursting fracture, 2 cases of spontaneous discitis and 2 cases of vertebral tumor in this series. Results The period of follow-up lasted 8 months, ranging from 6 to 21 months. The implant was healed after 3 or 4 months postoperatively. The reconstructive height of vertebra was maintained. The neural symptoms were improved in different degree. Conclusion The biomimetic and supportive n-HA/PA66 composites can effectively restore the height and structure of vertebra, and can be fused with vertebral body to reconstruct spinal structural stability effectively. And they can be extensively used in clinic.

关 键 词：纳米 羟基磷灰石 聚酰胺66 生物材料 脊柱前路重建术 

分 类 号：R318.08[医药卫生—生物医学工程] R683.2[医药卫生—基础医学]