犬应用吡喹酮缓释剂后血药浓度的检测  

DETECTION OF PRAZIQUANTEL CONCENTRATIONS IN PLASMA OF DOG AFTER ADMINISTRATION WITH SUSTAINED RELEASE DRUGS

作　　者：刘金凤[1] 田广孚[1] 张军[1] 贾万忠[1] 凌凤香[2] 赵亮[2] 樊立民[2] 

机构地区：[1]中国农科院兰州兽医研究所,730046 [2]中科院兰州化学物理研究所

出　　处：《中国兽医寄生虫病》1997年第1期15-18,共4页Chinese Journal of Veterinary Parasitology

基　　金：国家科技攻关项目

摘　　要：应用反相高效液相色谱法测定犬用吡喹酮缓释剂后的血药浓度。犬应用包埋缓释剂后1～7个月血药浓度为0．48～1．45μg／ml；犬应用注射缓释剂后1～6个月血药浓度为0．051～0．2μg／ml；犬口服常用驱（杀）虫剂量后1～8小时的血药浓度为0．66～1．60μg／ml。显然前者与口服浓度相当，而后者则远远低于口服浓度；前者预防效果减虫率达98．46～100％，后者仅达55．65～65．11％；从而以确凿的数据证实犬用包埋型缓释剂的有效预防期至少在7个月以上。The praziquantel concentrations on the plasma of dogs were measured by reverse high performance liquid chromatography (rHPLC). The blood content of dogs given praziquantel sustained release implants was 0.48-1.45μg/ml from 1 to 7 months. and that of dogs given praziquantel sustained release injections was 0.050-0.2μg/ml from 1 to 6 months. It was reported tuat the blood concentration in dogs. which took the conventional pesticide doses of praziquantel orally. was 0.66-1.60μg/ml from 1 to 8 hours. obviously, the former is almost identical to this value while the latter is far lower. As a result, the implants had 98.46-100%protection rate in dog Echinococcus granulosus prophylaxis, and the injections had only 55.65-65.11% protection rate. These data have confirmed that the prophylactic period of the implant against E. granulosus are at least over 7 months.

关 键 词：吡喹酮缓释剂 高效液相色谱法 血药浓度 犬 

分 类 号：S858.292[农业科学—临床兽医学] S859.795[农业科学—兽医学]