川崎病患儿血清降钙素原水平变化的意义  

Significance of Changes of Serum Procalcitonin Concentrations in Children with Kawasaki Disease

作　　者：汪芸[1] 孙丽萍[1] 刘敏[1] 刘春燕[1] 赵地[1] 马官福[1] 王俐[1] 李尔珍[1] 

机构地区：[1]首都儿科研究所附属儿童医院小儿内科,北京100020

出　　处：《实用儿科临床杂志》2007年第9期667-668,670,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的观察川崎病(KD)患儿血清降钙素原(PCT)水平变化,探讨其在KD中的作用和意义。方法以2003年10月～2005年12月住院91例KD患儿为研究对象,同期健康儿童为对照组,测定其血清PCT水平并分析二者间差异;分析病程不同时期、有无感染及是否出现并发症等情况下患儿血清PCT水平变化。结果1.急性期74例、亚急性期14例KD患儿血清PCT为0.55(0.30～2.09)μg/L和0.49(0.19～0.50)μg/L,33例健康对照PCT为0.16(0.14～0.24)μg/L。急性期及亚急性期患儿与健康对照比较,其差异均有统计学意义(Pa<0.01);急性期与亚急性期比较,二者差异有统计学意义(P<0.05);2.病原学阳性30例KD患儿PCT水平0.53(0.28～0.88)μg/L,61例病原学阴性KD患儿PCT水平0.50(0.30～1.93)μg/L,二者差异无统计学意义(P>0.05);3.冠脉扩张患儿33例PCT为0.50(0.32～0.60)μg/L,58例冠脉无扩张患儿PCT为0.52(0.30～2.17)μg/L,二者差异无统计学意义(P>0.05);4.无其他系统并发症65例PCT为0.47(0.27～0.80)μg/L,其他系统并发症26例PCT为0.83(0.48～4.41)μg/L,二者差异有统计学意义(P<0.01);当PCT≤0.5时,其他系统并发症发生率为22.2%;当PCT>0.5时,其他系统并发症发生率为42.9%,二者差异有统计学意义(P<0.05)。结论KD患儿血清PCT水平增高,尤以急性期明显,检测其水平有助于监测KD病程发展;有无并冠脉扩张KD患儿中PCT水平变化不大;并其他系统并发症KD患儿血清PCT水平显著增高,随PCT增高,发生其他系统并发症的可能性增大。Objective To study the changes of serum procalcitonin （PCT） levels and explore the role of PCT in Kawasaki disease （KD）. Methods From Oct. 2003 to Dec. 2005, ninety - one children suffering from KD and 33 healthy children were recruited in this study. Ninety - one KD patients were divided into different groups, such as acute, subacute and convalescent groups; infection and non - infection groups; complication and non - complication groups. Serum PCT concentrations of KD patients were compared with health children, and compared with different groups. Results 1. Serum PCT concentrations of KD patients were 0.55 （0.30 - 2.09） μg/L in acute phase, 0.49 （0.19 -0.50） μg/L in subacute phase. There was a significant difference between them （P 〈 0.05 ） ;Serum PCT concentrations in healthy children were 0.16（0.14 - 0.24） μg/L, there was a significant difference between acute patients and health children（ P 〈 0.01 ）, and so did subacute patients ;2. PCT levels were 0.53 （0.28 -0.88）μg/L in patients who had infections, and were 0.50 （0.30 -1.93 ）μg/L in patients without infection. There was not a statistical difference between them（ P 〉 0.05 ）. 3. In patients with or without coronary artery dilatation, PCT concentrations were 0.50 （0.32 - 0.60） μg/L and 0.52 （0.30 - 2.17 ） μg/L, there was not a statistical difference between them （P 〉 0.05 ）. 4. Serum concentrations of PCT were significantly higher in patients with noncardiac complication as compared to those without noncardiac complication, 0.83 （0.48 - 4.41 ） μg/L vs O. 47 （ 0.27 - 0.80 ） μg/L, P 〈 0.01. Noncardiac complications occurred in 22.2 % （ 14/63 ） acute patients if PCT levels were ≤0.5 μg/L, the incidence increased to 42.9% （ 12/28 ） if PCT levels were 〉 0.5 μg/L. There was a significant difference between them （ P 〈 0.05 ）. Conclusions The levels of serum PCT are markedly elevated in all patients with KD, especially in acute patients, and then gradually decreased f

关 键 词：黏膜皮肤淋巴结综合征 降钙素原 并发症 

分 类 号：R725.4[医药卫生—儿科]