动态脉压与原发性高血压早期肾损害的相关性研究  

The relative study of 24 hours mean pulse pressure and early renal impairment in essential hypertension

作　　者：郭皓[1] 翟彪[1] 田青[1] 王玮[1] 胡大春[1] 

机构地区：[1]昆明市第一人民医院心血管内科,云南省650011

出　　处：《中国心血管病研究》2007年第6期426-428,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨原发性高血压患者动态脉压(24hPP)与早期肾损害的关系。方法将原发性高血压患者125例按24hPP≤40mmHg、41～55mmHg、56～70mmHg、>71mmHg分为Ⅰ、Ⅱ、Ⅲ、Ⅳ组,测量动态血压参数、尿微量白蛋白(mA1b)、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG),比较各组的尿mA1b、NAG检测值及其阳性率,行24hPP与尿mA1b、NAG的相关回归分析。结果①Ⅰ组与Ⅱ组之间,尿mA1b、NAG及微量蛋白尿阳性率差异无统计学意义(P>0.05),Ⅱ、Ⅲ、Ⅳ组随24hPP的增高,尿mA1b、NAG及微量蛋白尿阳性率均依次明显增高,各组间差异有统计学意义(P<0.05)。②24hPP与尿mA1b、NAG呈正相关(r=0.79、0.78,P<0.05)。结论原发性高血压患者24hPP与尿mA1b、NAG呈正相关,当24hPP>57mmHg时,易出现高血压性早期肾损害。Objective To investigate the relationship between 24 hours mean pulse pressure and early renal impairment in essential hypertension patients. Methods 125 essential hypertension patients were studied. The data was collected and studied, which includes： 24 hours mean pulse pressure （24 h PP） of ABPM, urine microalbumin （mAlb） and n-acetyl- β-d-glucosaminidase （NAG）. The subjects were divided into four groups on the basis of the 24 h PP： group Ⅰ （≤40 mm Hg）, group Ⅱ （41-55 mm Hg）, groupⅢ（56-70 mm Hg）, group Ⅳ（〉71 mm Hg）. The urine mAlb, NAG and microproteinuria in each groups were compared respectively. And correlationship between 24 h PP and urine mAlb, NAG was analyzed. Results （1）Urine mAlb, NAG and microalbuminuria were not significant difference in the group Ⅰ and group Ⅱ （P〉0.05）. Urine mAlb, NAG and microproteinuria increased accordingly with ascending level of 24 h PP in groups II , Ⅲ and Ⅳ （P〈0.05）. （2）The urine mAlb and NAG were positively correlated with 24 h PP （r=0.79,0.78,P〈0.05）. Conlusion （1）The urine mAlb and NAG were positively correlated with 24 h PP. （2）The hypertensive renal impairment was affected easily when the 24 h PP〉57 mm Hg in essential hypertension patients.

关 键 词：高血压 脉压 肾功能衰竭 

分 类 号：R544.1[医药卫生—心血管疾病]