创伤时患者血清P-选择素的变化及临床意义  

ALTERATION IN SERUM AND CLINICAL SIGNIFICANCE OF P-SELECTIN IN TRAUMATIC PATIENTS

作　　者：陈荣剑[1] 林洪武[1] 彭咏梅[1] 张立[1] 叶祥燕[1] 黄宗海[2] 

机构地区：[1]解放军第184医院外科,鹰潭335000 [2]南方医科大学附属珠江医院普外科,广州510282

出　　处：《广西医科大学学报》2007年第2期208-209,共2页Journal of Guangxi Medical University

基　　金：南京军区医学科学技术研究"十一五"计划课题(编号06MA81)

摘　　要：目的:探讨创伤时患者血清中P-选择素的变化及意义。方法:采用酶联免疫法(ELISA)测定92例创伤患者血清中P-选择素水平。结果:正常对照组血清中P-选择素即有表达,创伤患者血清中P-选择素含量明显高于对照组,并且与创伤的严重程度明显相关。结论:创伤可导致血清中P-选择素大量表达,这与创伤时存在明显的微循环紊乱和内皮功能障碍有关。Objective. To investigate the alteration and significance of P-selection in serum during trauma. Methods： The serum level of P-selectin in 92 cases of traumatic patients was determined with ELISA. Resuit： The P-selectin was expressed in normal control. The level of P-selectin was significantly increased in traumatic patients and is correlating with the degree of trauma. Conclusion： The level of P-selectin is expressed in great quantity during trauma. It is related to the marked microcirculatory disturbance and endothelial dysfunction.

关 键 词：创伤 P-选择素 休克 

分 类 号：R64[医药卫生—外科学]