微小颗粒骨复合自体骨空心螺纹内固定器用于颈椎椎间融合△  

Experimental study of cervical interbody fusion with combined hollow threaded autograft fixator with morselized bone transplantation

作　　者：夏景君[1] 张志鹏[1] 闫景龙[1] 裴刘宝[1] 张砚[2] 安琪[3] 

机构地区：[1]哈尔滨医科大学附属第一医院骨外四科,150001 [2]哈尔滨师范大学附属医院 [3]哈尔滨医科大学

出　　处：《中国矫形外科杂志》2007年第10期762-764,共3页Orthopedic Journal of China

基　　金：国家自然科学基金项目(No.30371441)

摘　　要：[目的]研究微小颗粒骨与自体骨空心螺纹内固定器应用于颈椎椎体间融合情况,探讨微小颗粒骨作为一种新的移植材料的成骨特点。[方法]将绵羊18只用环钻行前路C3、4,C5、6双节段间盘切除,并分别植入自体髂骨及充填自体微小颗粒骨于自体皮质骨空心螺纹固定器内。术后行X线、组织学检查及力学测试。[结果]术后3个月实验组椎体间均获骨性愈合,对照组有1例未获得骨性愈合。力学测试显示两组有统计学差异,实验组好于对照组。[结论]自体骨螺纹内固定器内充填自体松质骨颗粒可以替代自体髂骨作为一种新型椎间移植材料;微小颗粒骨在牢固的内固定支持下可以获得较好的脊柱融合。[ Objective] To study cervical hollow threaded autograft cortical bone fixator with morselized bone for cervical anterior interbody fusion. [ Method] Eighteen sheep were underwent cervical anterior discectomy and fusion with a hollow threaded and fenestrated tibial cortical hone fixator filled with morselized bone （ diameter of 300 - 500 um） for C5,5 or autogenous iliac crest bone cylinder or C3,4 respectively. Cervical spines were radiographed immediately after surgery and 1,2,3 months later, the specimens of C5-6 and C3 -4 were taken for histology investigation and biomechanical test respectively. [ Result] Interbody fusion was achieved 3 months after surgery in experimental gronp and all but one in control group, with statisticdly significant difference was found between two groups in biomechanical compression and torsion tests of ante or post-fatigue test （ P 〈 0.05 ）. Cervical lordosis and intervertebral height were maintained. [ Conclusion ] Hollow threaded and fenestrated autograft Cortical bone fixator filled with morselized hone in diameter of 300 - 500 um may use as substitute of iliac crest bone for anterior cervical interbody fusion, morselized bone can achieve better interbody spinal fusion supported by ragid internal fixation.

关 键 词：颈椎 内固定 微小颗粒骨 

分 类 号：R687.3[医药卫生—骨科学]