Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice  

作　　者：WU Qing-tian MA Qing-jie HE Cheng-yan WANG Cai-xia GAO Shi HOU Xia MA Tong-hui 

机构地区：[1]Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China [2]China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China [3]School of Basic Medicine, Jamasi University, Jamasi 154002, P. R. China

出　　处：《Chemical Research in Chinese Universities》2007年第3期297-299,共3页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos30470405 and 30670477);National Natural ScienceFund for Distinguished Young Scholars(No30325011);Distinguished Young Scholars Fund of Jilin Province(No20030112);Excellent Young Tea

摘　　要：An overt phenotype of aquaporin-1 knockout（AQP1 ko） mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density（ BMD）, bone calcium and phosphorus contents, and bone metabolism in an AQP1 ko mouse model. The BMD of femurs in AQP1 ko mice was significantly lower than that of litter-matched wildtype mice as measured by dual energy X-ray absorptiometry. Consistently, the contents of bone total calcium and phosphorus were also significantly lower in AQP1 ko mice. The reduced BMD caused by AQP1 deficiency mainly affect male mice. Bone metabolic activity, as indicated by 99m^Tc-MDP absorption measurements, was remarkably reduced in AQP1 ko mice. These results provide the first evidence that AQP1 play an important role in bone structure and metabolism.An overt phenotype of aquaporin-1 knockout（AQP1 ko） mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density（ BMD）, bone calcium and phosphorus contents, and bone metabolism in an AQP1 ko mouse model. The BMD of femurs in AQP1 ko mice was significantly lower than that of litter-matched wildtype mice as measured by dual energy X-ray absorptiometry. Consistently, the contents of bone total calcium and phosphorus were also significantly lower in AQP1 ko mice. The reduced BMD caused by AQP1 deficiency mainly affect male mice. Bone metabolic activity, as indicated by 99m^Tc-MDP absorption measurements, was remarkably reduced in AQP1 ko mice. These results provide the first evidence that AQP1 play an important role in bone structure and metabolism.

关 键 词：AQUAPORIN Gene knockout Bone mineral density Bone metabolism 

分 类 号：R681[医药卫生—骨科学]