非洛地平对高血压病病人脑卒中及心血管事件影响的研究  

Effects of Felodipine on Cardiovascular and Cerebrovascular Events in patients with Essential Hypertension

作　　者：邢福泰[1] 刘世方[2] 冀林荣[2] 李占海[2] 史广萍[2] 

机构地区：[1]山西省大同市第四人民医院 [2]山西省大同市第五人民医院

出　　处：《中西医结合心脑血管病杂志》2007年第6期480-481,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家"十五"攻关课题基金资助项目(NoG98-1709)

摘　　要：目的探讨非洛地平预防高血压病病人脑卒中和心血管事件的作用。方法将符合条件的高血压病病人206例随机分为利尿剂加非洛地平组(治疗组,102例)和利尿剂加安慰剂组(对照组,104例),治疗随访期为5年,或至发生终点事件。随访时询问有关病情、测量血压、收集心脑血管事件及不良反应。结果治疗组血压始终低于对照组;治疗组脑卒中、心肌梗死以及总的心脑血管事件和总死亡数均较对照组明显降低(P<0.05或P<0.01)。结论高血压病病人应用非洛地平对预防脑卒中和心血管事件有益。Objective To evaluate the effect and safety of felodipine for the cardiovascular and cerebrovascular events in mild - to- moderate essential hypertension. Methods A total of 206 patients （pts） was randomized to diuretic group and felodipine group, 104 pts received either diuretic placebo. All pts were followed - up for an average of 60 months at 3 - month intervals. Results The systolic blood pressure/diastolic blood pressure was 158/92 mmHg for all pts. Following the treatment, the systolic blood pressure/diastolic blood pressure was 136.8/81.6 mmHg in the felodipine group, and that was 142.5/85.9 mmHg in the placebo group. The endpoint events （fetal and nonfetal stroke）, all cardiovascular events, all cardiac and cerebral hemorrage or embolism events, death by any cause, events, heart failure, cardiovascular death in the felodipine group were lower significant than that in the placebo group （P〈0.05）. Conclusion Felodipine was effective and safe for the essential hypertension.

关 键 词：高血压 非洛地平 脑卒中 心血管事件 

分 类 号：R544.1[医药卫生—心血管疾病] R255.3[医药卫生—内科学]