玻璃微流控芯片表面改性的微观机理研究  

Investigation on micro-modification mechanism on surface of microfluidic glass chip

作　　者：李宝兴[1] 叶美英[1] 褚巧燕[1] 俞健[1] 

机构地区：[1]杭州师范学院物理系,化学系,杭州师范学院有机硅化学及材料技术教育部重点实验室和微流控芯片研究所,杭州310036

出　　处：《物理学报》2007年第6期3446-3452,共7页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:10674039);高等学校全国优秀博士学位论文作者专项资金(批准号:200320);浙江省自然科学基金(批准号:R405097)资助的课题~~

摘　　要：在玻璃微流控芯片通道表面用硅烷化试剂二氯二甲基硅烷进行处理后,二氯二甲基硅烷与玻璃通道表面的硅羟基反应,硅烷基覆盖在原来的硅羟基上,其结果为电渗流减小甚至完全消除.进一步采用全势能线性糕模轨道分子动力学方法,对表面反应的微观结构进行了理论计算,计算结果表明硅羟基中的氢原子与二氯二甲基硅烷中的氯原子结合形成稳定的HCl分子结构而脱离,从而使硅烷基覆盖在表面上.The surface of the glass channel of microfluidic chip is treated with dichlorodimethylsilan. After the treatment, the silicon hydroxyl on the surface of the glass channel is silylated, which results in the reduction or even the elimination of the electroosmotic flow. Furthermore, full-potential linear-muffin-tin-orbital molecular dynamics method is used to investigate the micro -mechanism of surface reaction theoretically. The calculation results indicate that the hydrogen atom in silicon hydroxyl binds with the chlorine atom in dichlorodimethylsilan to form a stable HCl molecule and goes off, thereby the surface of the channel is covered with silylane.

关 键 词：微流控芯片 二氯二甲基硅烷 分子动力学方法 微观稳定结构 

分 类 号：TN492[电子电信—微电子学与固体电子学]