夹闭大鼠双侧颈总动脉对胃运动的影响  

Effects of Ligation of Bilateral Common Carotid Arteries on the Gastric Motility in Rats

作　　者：王林婕[1] 徐莉[1] 孙一耕[1] 艾洪滨[1] 

机构地区：[1]山东师范大学生命科学学院,山东济南250014

出　　处：《生物医学工程研究》2007年第1期59-61,70,共4页Journal Of Biomedical Engineering Research

基　　金：山东省自然科学基金资助项目(Y2002D18)

摘　　要：采用动脉夹夹闭大鼠双侧颈总动脉,胃内放置水囊记录胃运动的方法,观察了脑供血不足对胃运动的影响。结果表明：（1）夹闭30 min过程中,最初2 min内的胃运动指标（收缩频率、总收缩时程、总收缩幅度、胃运动指数）较夹闭前2 min内抑制显著;夹闭第28-30 min（即松开动脉夹前2min内）的胃运动各项指标较夹闭前2min均无显著差异。（2）松开动脉夹30min过程中,松开后最初2 min内与松开前2min内相比,胃运动抑制显著;但松开后第28-30 min的胃运动与松开前2min内的胃运动相比,无显著差异。这些结果说明：夹闭双侧颈总动脉造成脑局部供血不足初期,对胃运动有抑制作用,但随着结扎时间的延长,这种抑制作用逐渐消除,可能是椎-基底动脉环起了代偿作用。The effects of bilateral carotid ligation on the gastric motility were observed, The results were as follows： （ 1 ） during bilateral carotid ligation for 30 min period, the gastric motility within the initial 2 min was significantly inhibited compared with that before ligation （ P 〈 0.05）, but that of the 28 - 30th min returned by and large to the level before ligation. （2） during withdrawing ligation for 30 rain period, within the initial 2 min, the gastric motility was again inhibited compared with that of the 28th - 30th min during ligation（ P 〈 0.05 ）. The gastric motility in the last 2 min after withdrawing ligation didn＇ t show significant changes compared with that of 2 min before withdrawing ligation. These results suggest that the gastric motility can be inhibited in the initial stage of cerebral ischemia by ligating bilateral carotid in rats, but this inhibitory effect would be gradually eliminated with the prolonging of ligating time, this is maybe the compensated effect of cerebral arterial circulus or Willis cireulus.

关 键 词：大鼠 颈内动脉 WILLIS环 脑供血不足 胃运动 

分 类 号：R318[医药卫生—生物医学工程] Q426[医药卫生—基础医学]