吸毒者ALT水平及其与乙肝 丙肝病毒感染的关系  

Investigation on ALT Levels and Relationship between ALT and Hepatitis B and C Virus Infection in Drug Addicts

作　　者：郭永炼 吴统健 孙林渥 包炳辉 林亚毅 

机构地区：[1]福建省厦门市仙岳医院,厦门市361012

出　　处：《医药论坛杂志》2007年第9期22-23,共2页Journal of Medical Forum

摘　　要：目的探讨吸毒人群中丙氨酸氨基转移酶(ALT)水平以及与乙肝病毒(HBV)、丙肝病毒(HCV)感染之间的关系。方法对2006年1月-2006年9月到厦门市仙岳医院检查的768名吸毒人员血清中ALT的进行检测,同时进行了乙型肝炎病毒表面抗原(HBsAg)和抗丙型肝炎病毒抗体(抗-HCV)检测,并与同期检测ALT、HBsAg、抗-HCV的对照组进行比较。结果768例吸毒人员ALT水平显著高于512例对照组,两组比较的差异有统计学意义(χ2=193.58,P<0.01);768例吸毒人员HBV感染率与1171名对照组之间比较无显著性差异(χ2=2.249,P>0.05);768例吸毒人员HCV感染率与289例对照组之间比较有显著性差异(χ2=247.83,P<0.01);吸毒者单纯感染HCV组的ALT水平显著高于单纯感染HBV组,两组比较的差异有统计学意义(χ2=54.13,P<0.01)。结论吸毒者有明显的肝功能损害;吸毒者HCV感染情况要比HBV感染更为严重,在影响肝功能的过程中,HCV感染的作用要明显大于HBV感染的作用,吸毒者ALT的异常主要与HCV感染有着明显的关系。Objective To investigate on ALT levels and the relationship between ALT and hepatitis B and C virus infection in drug addicts. Methods ALT, HBsAg and anti - HCV in serum in 768 cases of drug addicts was determined in Xianyue Hospital of Xiamen from January 2006 to September 2006, and was compared with that among the control group. Results The ALT levels in serum in 768 cases of drug addicts was higher than that among the control group 512 cases （χ^2 = 193.58, P 〈0. 01 ） ;The rates of HBsAg positive were no significant difference between 768 cases of drug addicts and 1171 persons of the control group （χ^2 = 2. 249, P 〉 0. 05 ） ; The rates of anti - HCV positive in 768 cases of drug addicts was higher than that among 289 persons of the control group（χ^2= 247. 83, P 〈 0. 01 ） .The ALT level of only anti - HCV positive group is higher than that of only HBsAg positive group in drug addicts （χ^2= 54. 13, P 〈 0. 01 ）. Conclusion The function of liver in drug addicts was obviously damaged and the hepatitis C virus infection is the main effect.

关 键 词：吸毒者 ALT HBV HCV 

分 类 号：R512.6[医药卫生—内科学]