高龄患者使用左氧氟沙星对肾功能的影响  

Effect of levofloxacin on renal function in elderly patients

作　　者：张玉秋[1] 石宁江[1] 郑青[1] 石娜[1] 刘东[1] 林慧珠[1] 

机构地区：[1]清华大学玉泉医院,北京100049

出　　处：《中国药物应用与监测》2007年第2期51-52,64,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨高龄患者使用左氧氟沙星对肾功能的影响。方法:采用自身对照和药物对照方法,观察组和对照组每天分别给予左氧氟沙星0.4g、头孢哌酮3g～4g,均分2次静脉滴注,连续用药7d～10d。观察用药前后肾功能各项指标的变化。结果:治疗前后血肌酐值、血尿素氮、血和尿β2微球蛋白无显著性差异(P>0.05),组间比较也无显著性差异(P>0.05),用药后肾功能各项指标好于用药前。结论:疾病状态对肾功能的影响远远大于药物的影响。高龄患者存在轻度肾功能损伤,每日使用左氧氟沙星0.4g,分两次给予,连续用药7d～10d安全有效,对肾功能影响不明显。Objective：To study the effect of levofloxacin on renal function in elderly patients.Methods：Self-control and drug- control methods were used to observe the variations of renal function after levofloxaein （0.4g） or eefoperazone （3g-4g） were administed both twice daily intravenously for 7d-10d.Results：There were no significant differences in SCr,BUN,blood and urine β2-MG before and after treatment （P〉0.05）, and there were no significant differences between the two groups too （P〉0.05）. Th3 indexes of renal function after therapy were better than that before therapy.Conclusion：The effect of disease state on renal function is much greater than that of drugs. Levofloxaein （0.4g, twice daily intravenously for 7d-10d） is safe and effective, and has no significant effect on renal function in elderly patients.

关 键 词：高龄 左氧氟沙星 肾功能 

分 类 号：R96[医药卫生—药理学]