老年全身炎症反应综合征患者血清D-二聚体和C反应蛋白检测的意义  

Significance of D-dimer and C-reactive protein in the elderly patients with systemic inflammatory response syndrome

作　　者：张芝晶[1] 胡叶[1] 李洪芳[2] 

机构地区：[1]大连市中心医院急诊ICU,辽宁116033 [2]沧州市传染病医院,河北061001

出　　处：《中国急救医学》2007年第6期501-503,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的研究D-二聚体、C反应蛋白(CRP)检测在老年全身炎症反应综合征(SIRS)向多器官功能障碍综合征(MODS)转化中的临床意义。方法老年患者240例分为SIRS组和非SIRS组,SIRS组190例再分为MODS组与非MODS组,常规测定各组患者APACHEⅡ评分,分别用ELISA法测定血清D-二聚体水平,全自动生化分析仪免疫比浊法测定CRP水平。结果发病后24h内SIRS组D-二聚体和CRP水平明显高于非SIRS组(P<0.01)。MODS组患者血D-二聚体和CRP水平明显高于非MODS组(P<0.05)。D-二聚体与预后呈负相关(r=-0.2879,P<0.01)。结论检测SIRS患者血清CRP和D-二聚体水平有助于早期诊断MODS并判断预后。Objective To discuss the clinical significance of D - dimer and C - reactive protein （CRP） in the elderly patients with systemic inflammatory response syndrome （SIRS） and/or multiple organ dysfunction syndrome （ MODS ）. Methods Data of 240 the elderly patients were collected. The level of D - dimer was measured by ELISA, and CRP was detected by immuno - turbidimetric method with automatic biochemical analysis. Results The level of D - dimer and CRP were higher in the elderly patients with SIRS than in those without SIRS, there were statistically significant differences （P 〈 0. 01 ）. The levels of D - dimer and CRP were significantly higher in SIRS patients with MODS than in those with- out MODS, there were statistically significant differences （ P 〈 0.05 ）. There was obviously negative corre- lation between D - dimer and the prognosis in the elderly patients with SIRS （ r = - 0 . 2879, P 〈 0.01 ）. Conclusions The measurement of D - dimer and CRP was helpful to the early diagnosis of MODS and the evaluation of prognosis in the elderly patients with SIRS.

关 键 词：D-二聚体 C反应蛋白 全身炎症反应综合征 多器官功能障碍综合征 

分 类 号：R459.7[医药卫生—急诊医学] R446.6[医药卫生—治疗学]