抗生素不同用药方案预防乳癌手术部位感染的成本效果分析  

Cost-effectiveness analysis between different usage of antibiotic prophylaxis for preventing the surgical site infection in the breast cancer patients

作　　者：梅逸静[1] 白迎雪[1] 许现芬[1] 李玉鸣[2] 王欢[3] 

机构地区：[1]山东中医药大学第二附属医院普外科,济南25000 [2]山东中医药大学第二附属医院药剂科,济南25000 [3]济南市妇幼保健院病案室

出　　处：《医学信息（手术学分册）》2007年第3期238-239,241,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的探讨抗生素不同用药方案对乳癌术后手术部位感染的预防效果和成本的影响。方法506例乳腺癌改良根治手术患者随机分为观察组(n=253)和对照组(n=253)。观察组术前半小时静脉滴注头孢曲松2.0g;对照组术后3d每天静脉滴注头孢曲松2.0g。观察和记录术后患者手术部位感染情况并计算感染有关的医疗成本。结果术后感染发生率观察组和对照组分别为1.19%(3/252)和1.58%(4/253),其中手术部位感染共6例(1.19%),观察组和对照组各3例(1.19%),差异无统计学意义(P>0.05);对照组呼吸道感染1例。预防和治疗术后感染的直接医疗费用观察组为(163±78)元,对照组为(388±134)元,差异有统计学意义(P<0.05)。结论成本-效果分析表明,术前单次头孢曲松在预防手术部位感染方面与对照组等效,且医疗费用显著降低,具有更高的性价比。Objective To compare the cost - effectiveness between different usage of antibiotic prophylaxis for preventing the surgical site infection （SSI） in the breast cancer patients. Methods Five hundred and six patients with breast cancer were randomly divided into single -dose eeftriaxone group（ n = 253, receiving intravenously 2.0 g eeftriaxone 0. 5 hours prior to operation only） and eeftriaxone regular usage group（ n = 253, receiving 2.0 g eeftriaxone everyday after operation for 3 day）. The infectious complications were observed, and pharmaeoeeonomie parameters were ana- lyzed. Results There were not significantly different between groups in the morbidity of postoperative infection and SSI （ P 〉 0. 05 ）. The direct cost related to prevention and treatment of SSI was （ 163 ± 78 ） RMB in the single dose eeftriaxone group and （388 ±134） RMB in the regular usage group （P 〈 0. 05 ）. Condusions Both groups have the same effectiveness for prevention of SSI. But the cost is lower in the single - dose group than the control group related to prevention and treatment of SSI in the view of phamaeconomies.

关 键 词：感染 手术 抗生素 预防 经济学 药物 

分 类 号：R978.1[医药卫生—药品] R737.9[医药卫生—药学]