斑秃患者白介素1受体拮抗剂基因多态性研究  

Study of Interleukin-1 Receptor Antagonist Gene Polymorphism in Alopecia Areata

作　　者：张军民[1] 唐玉珠[1] 许彤华 刘贞富[1] 张德美[1] 杨琦[1] 

机构地区：[1]同济医科大学附属协和医院皮肤科,武汉430022

出　　处：《中华皮肤科杂志》1997年第1期19-20,共2页Chinese Journal of Dermatology

摘　　要：斑秃是与遗传相关的多因素皮肤炎症性疾病。白介素1及其受体拮抗剂在皮肤炎症反应中起重要作用,白介素1受体拮抗剂基因呈多态性。本研究旨在探讨其多态性在斑秃发病机理中的作用。采用聚合酶链反应方法研究了72例斑秃患者和130例正常对照者的白介素1受体拮抗剂基因型。结果:斑秃患者A_2频率显著高于正常人。提示白介素1受体拮抗剂基因中A_2可能在斑秃的病损严重度方面起作用。Alopeeia areata (AA) has been well recognized with familial tendencies, but the genetic basis of this clinical observation remains unknown. The cytokine interleukin-1 receptor antagonist (ILlra) is a potent anti-inflammatory protein that can prevent immune-mediated inflammatory response in the skin. We characterized a polymorphism within the gene for this cytokine ILlra in this study and tested the gene as a possible marker in patients with alopecia areata. We have determined allele frequencies of the polymorphic cytokine genes in a control population and a group of 72 patients with alopecia areata. The frequency of allele 2 of interleukin-1 receptor antagonist in patients with AA was significantly higher than that of control group. It suggests that interleukin-1 receptor antagonist gene may be a candidate gene or severity factor for alopecia areata.

关 键 词：斑秃 基因 多态性 白细胞介素1 受体 拮抗剂 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]