海绵共附生微生物次级代谢产物的研究进展  

Progress in Studies on Secondary Metabolites of Sponges-Associated Microorganisms

作　　者：朱伟明[1] 张敏[1] 方玉春[1] 朱天骄[1] 顾谦群[1] 

机构地区：[1]中国海洋大学教育部海洋药物重点实验室海洋药物与食品研究所,山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2007年第3期377-384,共8页Periodical of Ocean University of China

基　　金：山东省自然科学基金项目(Z2006C13);国家高技术研究发展计划项目(2003AA624020)资助

摘　　要：海绵独特的摄食、滤食系统使其体内体表富集了大量的微生物,这些微生物能够产生多种结构新颖的生物活性物质,对海绵共附生微生物的研究正在成为开发海洋药物资源的重要内容之一。本文按化合物的生源途径及其结构类型简要介绍近几年来海绵共附生微生物次级代谢产物及其生物活性的研究进展。Because of their unique ingestion and digest system, marine sponges enrich large numbers of microorganisms interiorly and exteriorly that make up a kind of special ecosystem. Novel bioactive substances were isolated and identified from microorganisms associated with sponges, which is important in drug discovery. The recent studies on the new bioactive secondary metabolites of symbiotic or epibiotic microorganisms with sponges are reviewed in this paper in terms of their structural types, biogenesis and biological activities.

关 键 词：海绵 共附生微生物 次级代谢产物 

分 类 号：S917.1[农业科学—水产科学] R282.77[医药卫生—中药学]