老年2型糖尿病并急性脑血栓形成与C肽等关系探讨  

Investigation on Relationship Between Acute Cerebral Thrombosis and C-peptide in Elderly Type 2 Diabetic Patients

作　　者：陈敏[1] 胡湘明[1] 朱筱[1] 何霞[1] 

机构地区：[1]湖南省长沙市第四医院内分泌科,湖南长沙410006

出　　处：《医学临床研究》2007年第5期786-788,共3页Journal of Clinical Research

摘　　要：【目的】探讨老年2型糖尿病并急性脑血栓形成的危险因素。【方法】对76例老年2型糖尿病并脑血栓形成(C组)患者与76例糖尿病不合并脑血栓形成(B组)及76例老年无糖尿病有脑血栓形成(A组)患者进行临床和生化指标的检测。【结果】C组与B组相比,收缩压(SBP)、空腹C肽(Fc-p)均高于B组(P<0.05),空腹血糖(FBS)、病程低于B组(P<0.05);B组与A组相比,糖化血红蛋白(HbA1c)、FBS、尿素氮(BUN)、肌酐(Cr),B组高于A组(P<0.05),SBP、Fc-p,B组低于A组(P<0.05);C组与A组相比,HbA1c、FBS、BUN高于A组(P<0.05),Fc-p、高密度脂蛋白胆固醇(HDL-ch),C组则低于A组(P<0.05)。logistic回归方程发现收缩压、Fc-p、低密度脂蛋白胆固醇(LDL-ch)是糖尿病患者患脑血栓形成的危险因素,影响力度依次为LDL-ch>Fc-p>SBP。【结论】为防止老年人2型糖尿病急性脑血栓形成,降压、纠正血脂紊乱和改善胰岛素抵抗是重要的,控制血糖同样重要。[Objective]To investigate the risk factors of acute cerebral thrombosis in elderly type 2 diabetes mellitus. [Methods]Seventy-six patients of elderly type 2 diabetic patients complicated with （group C） or without （group B） cerebral thrombosis were compared with the patient with cerebral thrombosis, without diabetes mellitus （group A）. [Results]SBP and Fc-p in group C were higher than those in group B （ P 〈0.05）; the duration of diabetes mellitus and FBS in group C were lower than those in group B （ P 〈0.05）. HbAlc, FBS, BUN, CR in group B were higher than those in group A （ P 〈0. 05） ; SBP and Fc-p in group B were lower than those in group A （ P 〈0. 05）. HbAlc, FBS and BUN in group C were higher than those in group A （ P 〈0. 05） ; Fc-p and HDL-ch in group C were lower than those in group A （ P 〈0. 05）. Logistic regression analysis showed that SBP, Fc-p, and LDL-ch were risk factors of acute cerebral thrombosis in elderly type 2 diabetes mellitus, the affective strength was in order the LDL-ch, Fc-p and SBP. [Conclusion]To prevent the acute cerebral thrombosis in elderly type 2 diabetes mellitus, correcting dyslipidemia, controlling hypertension and blood glycerin and improving insulin resistance are very important.

关 键 词：糖尿病 非胰岛素依赖型/并发症 急性病 脑栓塞和血栓形成/并发症 C肤 

分 类 号：R587.1[医药卫生—内分泌]