长期低剂量YbCl_3暴露的神经毒性评价  

Neurotoxicity Evaluation of Long-Term Low-Level Ytterbium Chloride Exposure

作　　者：何潇[1] 张智勇[1] 冯流星[1] 李子杰[1] 姜文君[1] 赵宇亮[1] 柴之芳[1] 

机构地区：[1]中国科学院高能物理研究所核分析技术重点实验室,北京100049

出　　处：《中国稀土学报》2007年第3期349-354,共6页Journal of the Chinese Society of Rare Earths

基　　金：国家自然科学基金重大项目(10490181);中国科学院重要方向性项目(KJCX3-SYW-N3);中国科学院核分析技术重点实验室基金(K-104)资助

摘　　要：雌性Wistar大鼠受孕之日起以经口灌胃方式用YbCl3染毒,剂量为0.1,2.0和40 mg Yb.kg-1体重,对照组灌生理盐水。仔鼠出生后20 d断乳并用相同剂量的YbCl3染毒。用Morris水迷宫评价学习记忆能力,并尝试从大鼠体内微量元素含量变化、大脑海马体中Ca2+-ATP酶活性、海马细胞内游离钙水平及脂质过氧化程度等方面评价YbCl3的神经毒性。结果显示,2.0和40 mg.kg-1体重剂量的YbCl3长期暴露会对大鼠的学习记忆能力产生负面影响,这可能和YbCl3暴露引起的骨骼、血清、肝脏和各脑区中部分微量元素含量发生改变,Ca2+-ATP酶活性受到抑制,海马细胞内游离钙水平升高及脂质过氧化程度加剧等因素有关。Epidemiological survey of local populations residing in the lanthanide-high background regions showed that the intelligence quotient of children was obviously lower than that in the normal regions and close investigation of lanthanide neurotoxicity was demanded. To evaluate the effects of the heavy rare earth elements chronic exposure, the rat models of long-term ytterbium chloride exposure by orally administrating at a daily dose of 0. 1, 2 mg· kg^-1, or 40 mg ·kg^-1 for 6 months were established and the effects of ytterbium exposure on brain functions were elucidated from four aspects ： behavioral performance, elemental concentration in tissues, intracellular free Ca in hippcampal neurons and lipid peroxidation level. The results indicate that 2 and 40 mg·kg^-2 Yb exposure on rats could impair the learning and memory abilities while 0.1 mg·kg^-1 Yb exposure showed no obviously negative effect.

关 键 词：YbCl3 学习记忆 神经毒理 稀土 

分 类 号：S432.26[农业科学—植物病理学] S432.23[农业科学—农业昆虫与害虫防治]