Intercalation of Amido Cationic Drug with Montmorillonite  

作　　者：郑俊萍 

机构地区：[1]School of Materials Science and Engineering,Tianjin University

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2007年第2期250-252,共3页武汉理工大学学报（材料科学英文版）

基　　金：the National Natural Science Foundation of China (No.20204008)

摘　　要：The intercalation of drug molecules with montmorillonit （MMT） using Acyclovir （ACV） as the model drug was focused on. The optimum conditions were studied based on orthogonal design, such as intercalation time and temperature. The intercalation composites were characterized by X-ray diffraction （XRD）, Fourier transformed infrared （FT-IR）, and thermogravimetric analysis （TGA）. The experimental results reveal that ACV is successfully intercalated into the interlayers of MMT, The in vitro release experiments reveal that ACV is released from MMT steadily and pH dependent.The intercalation of drug molecules with montmorillonit （MMT） using Acyclovir （ACV） as the model drug was focused on. The optimum conditions were studied based on orthogonal design, such as intercalation time and temperature. The intercalation composites were characterized by X-ray diffraction （XRD）, Fourier transformed infrared （FT-IR）, and thermogravimetric analysis （TGA）. The experimental results reveal that ACV is successfully intercalated into the interlayers of MMT, The in vitro release experiments reveal that ACV is released from MMT steadily and pH dependent.

关 键 词：MONTMORILLONITE ACYCLOVIR intercalation： in vitro release 

分 类 号：O621.2[理学—有机化学]