Biocompatibility of Tri-block Bone-matrix Material in vitro  

作　　者：段德宇 

机构地区：[1]Department of Orthopedics,Union Hospital,Tongji Medical College of Huazhong University of Science and Technology

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2007年第2期284-287,共4页武汉理工大学学报（材料科学英文版）

基　　金：the National Natural Science Foundation of China(No.30200063,30470483,30170270);the Excellent Youth Foundation of Wuhan Science and Technology Committee(No. 20045006071-10)

摘　　要：To evaluate the biocompatibility of poly（lactic acid/glycolic acid/ asparagic acid-copolyethylene glycol）（PLGA-[ASP-PEG]） tri-block copolymer in vitro, L929 fibroblast was co-cultured with the copolymer for cytotoxicity, hemolysis and pyrogen tests. And, compared with PLGA, the adhesiveness rate of the copolymer was calculated. The experimental results show that the toxicity gradation of the material was 0-1; L929 fibroblasts had a good cell morphology and proliferated rapidly on the surface of the material; hemolysis ratio was 3.08%; there was no pyrogen reaction. The adhesiveness of PLGA-[ASP-PEG] was better than that of the PLGA＇s（P〈0.05）. The results confirm that the PLGA-[ASP-PEG] has a good biocompatibility.To evaluate the biocompatibility of poly（lactic acid/glycolic acid/ asparagic acid-copolyethylene glycol）（PLGA-[ASP-PEG]） tri-block copolymer in vitro, L929 fibroblast was co-cultured with the copolymer for cytotoxicity, hemolysis and pyrogen tests. And, compared with PLGA, the adhesiveness rate of the copolymer was calculated. The experimental results show that the toxicity gradation of the material was 0-1; L929 fibroblasts had a good cell morphology and proliferated rapidly on the surface of the material; hemolysis ratio was 3.08%; there was no pyrogen reaction. The adhesiveness of PLGA-[ASP-PEG] was better than that of the PLGA＇s（P〈0.05）. The results confirm that the PLGA-[ASP-PEG] has a good biocompatibility.

关 键 词：tissue engineering biomaterial polylactic acid（PLA） BIOCOMPATIBILITY 

分 类 号：O631.3[理学—高分子化学]