丹参总酚酸脂质体的制备和药剂学性质  

Preparation and pharmaceutical properties of total salvianolic acids liposomes

作　　者：张丽红[1] 张志荣[1] 韩丽妹[2] 王建新[2] 

机构地区：[1]四川大学华西药学院药剂教研室,成都610041 [2]复旦大学药学院药剂学教研室,上海200032

出　　处：《复旦学报（医学版）》2007年第3期391-395,共5页Fudan University Journal of Medical Sciences

摘　　要：目的研究丹参总酚酸(TSA)脂质体的制备方法并考察其药剂学性质。方法采用逆向蒸发法制备TSA脂质体,以包封率和粒径为指标,应用正交试验设计法优化处方,并对其表面特征、包封率、粒径、pH值、体外释放等性质进行考察。结果所得脂质体外观光滑圆整,分散性好,包封率为72．0％,粒径为(145．3±58．7) nm,pH为4．07,体外24 h累计释放46．8％,释放动力学符合weibull方程。结论制备的TSA脂质体具有包封率高、粒径小、良好的缓释作用等特点,为进一步研究奠定了基础。Purpose To study the preparation method and pharmaceutical properties of total salvianolic acids liposomes. Methods Reverse-phase evaporation technique was chosen to prepare liposomes and orthogonal design was used to optimize the formulation. Then properties of liposomes including morphology, encapsulation efficiency, mean diameter, pH and accumulative release were studied. Results The liposomes were smooth and spherical. Encapsulation efficiency, mean diameter and pH of them were 72.0%, （145.3 ± 58.7 ）nm and 4.08 respectively. After 24 hours, 46. 8% of the total drug was released and the release kinetics can be described using Weibull Equation. Conclusions The size of liposomes was small, the encapsulation efficiency was high and the in vitro release was in a sustained way.

关 键 词：丹参总酚酸 丹酚酸B 脂质体 

分 类 号：R943[医药卫生—药剂学]