粗叶悬钩子根部提取物对急性肝损伤大鼠TNF-α IL-1β IL-6的影响  

The Influence of the Extracts of Rubus Alceaefolius Poir Root to TNF-α IL-1β IL-6 in Acute Liver Injuried Rats

作　　者：洪振丰[1] 周建衡[1] 李天娇[1] 叶蕻芝[1] 黄玲[1] 

机构地区：[1]福建中医学院中西医结合系

出　　处：《中华中医药学刊》2007年第6期1137-1138,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：福建省自然科学基金资助项目(C0210020)

摘　　要：目的:探讨粗叶悬钩子根部提取物对大鼠急性肝损伤的治疗作用。方法:以化学方法提取总生物碱、总多糖、总黄酮为治疗药物,通过一次性腹腔注射99.5%CCL4建立大鼠急性肝损伤模型,检测药物对大鼠血清TNF-α、IL-1β、IL-6含量的影响。结果:粗叶悬钩子根部总多糖能明显降低大鼠血清中异常增高的TNF-α、IL-1β、IL-6含量(P<0.01)减轻大鼠肝细胞坏死程度。总生物碱、总黄酮对大鼠血清TNF-α、IL-1β、IL-6含量有一定影响但没有统计学意义。结论:粗叶悬钩子根部总多糖具有减轻炎症因子对肝细胞造成损伤的作用。Objective ： To investigate pharmacological effects of some extracts of Rubus alceaefolius Poir root against acute hepatic injury. Methods ： Some extracts of Rubus alceaefolius Poir root were distilled by chemistry, the acute hepatic injury was induced by intraperitoneal injection with 99.5% CCL4 in rats and treated by alkaloids , Polysacharides , flavonoids, then observed the levels of TNF- α,IL - 1β,IL -6. Results： The total Polysacharides of Rubus alceaefolius Poir root can reduce the the abnormally high levels of TNF - α,IL - 1β,IL -6 and reduce the levels of injuried liver ceils, alkaloids and flavonoids have influence to TNF- α,IL- 1β,IL- 6 in some degree but the difference is not significant. Conclusion： The results indicated that the total Polysacharides of Rubus alceaefolius Poir root can reduce

关 键 词：粗叶悬钩子 总生物碱 总多糖 总黄酮 急性肝损伤 大鼠 

分 类 号：R285.5[医药卫生—中药学]