脑损伤后脑脊液和血清中C-反应蛋白动态变化的临床意义  

The clinical meaning of the development and changes of C-reactave protein(CRP)in CSF and serum after brain injured

作　　者：韩汝政[1] 李化伟[1] 耿正顺[1] 王其春[1] 翟瑞山[1] 

机构地区：[1]莱芜钢铁集团有限公司医院神经外科,山东莱芜271104

出　　处：《中国冶金工业医学杂志》2007年第3期255-257,共3页Chinese Medical Journal of Metallurgical industry

摘　　要：目的:研究颅脑损伤后不同阶段脑脊液(CSF)和血清中C-反应蛋白(CRP)的动态变化与脑损伤病情发展的关系。方法:将46例患者分成重型和轻中型分别为22例和24例并与10例正常(志愿者)对比,采用免疫浊度法在第1、3、7、14天时测定脑脊液和血清中CRP的含量变化,用统计学方法分析其数据。结果:重型组CSF和血清中CRP含量在受伤后1天内明显升高,7天达到高峰,维持14天,其水平均高于相应时段的轻中型组(P<0·05),两组均明显高于对照组(P<0·01),伤后到高峰期CSF中的含量显著高于血清(P<0·05);轻中型组中CRP水平在受伤后1天内明显升高,3天达到高峰,以后逐渐下降,14天时接近正常水平。结论:急性颅脑损伤后脑脊液和血清中早期CRP的水平与颅脑损伤的严重程度密切相关。CSF和血清中CRP是重型颅脑损伤患者急性期脑细胞损伤敏感指标,可以作为重型颅脑损伤患者危险性的独立预测因子,对判断病情、治疗效果及估计预后有重要意义。Objective ： To explore the development and changes of the C-reactive protein（CRP）in c erebrospinal fluid（CSF）and serum after brain injured,and investigate the relationship between of CRP and the brain injury. Methods：Expressions 46 cases and 10 normal with CRP and CRS by immunoturbidimetric assy. Results：The content of CRP was increased sharply with sever group at 1st day, attaining peak in 7 days up 14 days. A significant difference was noted between CSF and CRP levels in patients with sever injury and moderate injury（P〈0.05） ,two series of all obvious over comparisons series（P〈0. 01 ） ,the injury afterwards reaches the peak stage content among the CSF remarkably is more than serum（P〈0.05） ; The CRP level in light middle-sized series is obviously ascended inner place rear 1 day after wounded,attaiing the peak in 3 days,and drops one by one afterwards, 14 days were normal levels. Conclusions： These results support the use of serum CRP in the CSF for early estimation of the degree of brain injury and prognosis of patients with acute brain injury.

关 键 词：脑损伤 C-反应蛋白 

分 类 号：R651.15[医药卫生—外科学]