雄激素和雄激素受体与老年男性外周动脉硬化闭塞病的相关研究  

Relation between androgen,androgen receptor and peripheral arteriosclerotic occlusive disease in old males

作　　者：楚新梅[1] 李小鹰[1] 梁春红[1] 王珊[1] 郑华[1] 马芳玲[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《中华老年心脑血管病杂志》2007年第6期364-366,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：全军十五面上课题(01AM301)

摘　　要：目的探讨老年男性外周动脉硬化闭塞病患者的雄激素和雄激素受体水平变化。方法收集老年男性外周动脉硬化闭塞病患者44例(外周动脉硬化闭塞病组)和男性健康者104例(健康组),共检测血清中的7种性激素:黄体生成素、卵泡刺激素、总睾酮和雌二醇,采用化学发光法检测;游离睾酮,硫酸脱氢表雄酮和性激素结合球蛋白采用酶联免疫法检测。使用流式细胞技术测定外周淋巴细胞内雄激素受体含量。结果与健康组比较,外周动脉硬化闭塞病组患者腰围(90.75±8.38)cmvs(86.61±8.91)cm、腰臀比(0.91±0.05vs0.88±0.06),收缩压[(140.91±20.55)mmHgvs(130.03±16.69)mmHg,1 mmHg=0.133 kPa]、舒张压(83.07±14.15)mmHgvs(77.21±9.34)mmHg和雌二醇/总睾酮比值(7.32±3.32vs5.76±2.69)明显增高,而雄激素受体荧光强度(2.92±0.97vs3.36±1.05)明显下降。结论老年男性外周动脉硬化闭塞病患者雌二醇/总睾酮比值明显增高,雄激素受体含量明显降低。雄激素受体水平下降可能加速动脉粥样硬化发展。Objective To investigate the changes of androgen and androgen receptor levels in old male patients with peripheral arteriosclerotic occlusive disease. Methods A case control study was performed in 44 patients with peripheral arteriosclerotic occlusive disease and 104 controls aged 62-92 years. They were randomly selected from inhabitants in Wanshoulu area, Beijing. Luteinizing hormone （LH）, follicle-stimulating hormone （FSH）, estradiol （E2） and total testosterone （TT） were measured by chemiluminescence technique. Free testosterone （FT）, sex hormone binding globulin （SHBG） and dehydroepiandrosterone sulphate （DHEA-s） were measured by ELISA. Mean fluorescent channel （MFC） of androgen receptor in peripheral lymphocytes was analyzed by flow cytometry. Results Compared with healthy controls, waist circumference （90.75±8.38） cm vs （86.61±8.91） cm, waist-to-hip ratio （WHR,0. 91±0. 05 vs 0. 88±0.06）, SBP （140.91±20.55） mm Hg vs （130.03±16. 69） mm Hg,DBP （83.07±14. 15） mm Hg vs （77.21±9.34） mm Hg and E2/TT ratio （7.32±3.32 vs 5.76±2.69） were increased, but MFC （2.92±0.97 vs 3.36±1.05） was decreased significantly in patients with peripheral arteriosclerotic occlusive disease. Conclusion E2/TT ascended, MFC descended in old men with peripheral arteriosclerotic occlusive disease. Descending of MFC was likely to accelerate atherosclerosis.

关 键 词：雄激素 受体 雄激素 动脉硬化 闭塞性 危险因素 

分 类 号：R543[医药卫生—心血管疾病]