熊去氧胆酸联合复方茵陈注射液治疗胆汁性肝硬化的效果及成本分析  

Efficacy and Cost-Effectiveness Analysis of Ursodeoxycholic Acid and Yinchen Compound Injection in Treatment of Biliary Cirrhosis

作　　者：李冰[1] 王业东[1] 陈国凤[1] 

机构地区：[1]解放军第302医院,感染7科,北京100039

出　　处：《解放军药学学报》2007年第3期207-209,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的 研究熊去氧胆酸联合复方茵陈注射液治疗原发性胆汁性肝硬化（primary biliary cirrhosis,PBC）的临床疗效及所产生的成本.方法 86例原发性胆汁性肝硬化患者,分成单纯熊去氧胆酸（UDCA,13～15 mg·kg^-1·d^-1）组（56例）、熊去氧胆酸联合复方茵陈注射液组（30例）,疗程4周.治疗前、治疗后1、2、4周分别复查肝功能.采用配对设计t检验方法进行统计学分析.运用药物经济学成本-效果分析方法对这86例PBC的2种治疗方案在降黄效果方面进行回顾性分析评价.结果 86例患者治疗前主要表现为血清总胆红素（TBiL）、谷丙转氨酶（ALT）、谷草转氨酶（AST）呈轻、中度升高.治疗后两组病例ALT、AST、TBiL指标均明显降低,但联合治疗组的上述指标下降时间比UDCA组快.结论 单纯UDCA治疗组及联合治疗组肝功能均有好转,但后者好转更迅速,变化更明显.Aim To explore the clinical efficacy and the cost-effectiveness of two different groups of primary biliary cirrhosis（PBC） by Ursodeoxycholic Acid and Yinchen Compound Injection. Methods 86 patients with primary biliary cirrhosis were divided into 2 groups. 56 patients of PBC were observed with Ursodeoxycholic acid （UDCA） and another 30 PBC patients were observed with Ursodeoxycholic acid （UDCA） and Yinchen Compound Injection. Results After 4 weeks,both groups responded and the method of UDCA combined with Yinchen Compound Injection appeared better. Conclusion Treatment of either group was effective ,but was more effective for the combined group.

关 键 词：胆汁性肝硬化 熊去氧胆酸 复方茵陈注射液 成本-疗效 

分 类 号：R956[医药卫生—药学]