基于相干和互谱估计的延时基因网络构建  

Construction of time-delay gene networks using coherence and cross spectrum evaluation

作　　者：曹祥红[1] 戈民[1] 崔光照[1] 

机构地区：[1]郑州轻工业学院电气信息工程学院,河南郑州450002

出　　处：《郑州轻工业学院学报（自然科学版）》2007年第2期81-84,共4页Journal of Zhengzhou University of Light Industry:Natural Science

基　　金：国家自然科学基金项目(60573190)

摘　　要：针对基因之间的延时调控关系,从数字信号处理的角度将基因表达数据视为离散的时间序列,提出了基于小波去噪、相干和互谱估计的时间延迟基因网络构建方法,并初步构建了延时基因调控网络.该网络能够更好地反映生物现象的内部作用过程,为进一步分析基因之间的功能提供了参考.On the basis of gene time-delay regulatory relations, gene expression data are viewed as a set of discrete time series from signal processing perspectives. A scheme is put forward for gene networks construction by wavelet denoise, coherence and cross spectrum time-delay evaluation. Wavelet transform and reconstruction are applied to denoise gene expression time signals. Constructed gene network for selected data set is given out. The results demonstrate that our method can effectively reduce noise and detect time-delay relations between gene pairs at frequencies with high coherence.

关 键 词：基因网络 延时基因调控 互谱估计 

分 类 号：TN911.72[电子电信—通信与信息系统] TP301.6[电子电信—信息与通信工程]