PON2基因C311S、G148A多态性与脑卒中关系的研究  

Relationship between single nucleotide polymorphisms of paraoxonase 2 and stroke

作　　者：许宏伟[1] 赵真[1] 袁宁[1] 肖波[1] 杨晓苏[1] 唐北沙[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410008

出　　处：《中华医学遗传学杂志》2007年第3期328-330,共3页Chinese Journal of Medical Genetics

摘　　要：目的探讨对氧磷酶2（paraoxonase2,PON2）基因多态性与脑卒中的关系。方法用聚合酶链反应-限制性片段长度多态性分析法分别检测PON2基因C311S、G148A多态性在脑出血组（150例）、脑梗死组（180例）和正常对照组（120名）的基因频率。结果发现中国湖南地区人群存在PON2基因C311S、G148A多态性,在正常对照组中等位基因频率分别是S/C0.77/0.23,A/G0.43/0.57。脑出血组、脑梗死组患者PON2基因的等位基因频率与正常对照组相比差异无统计学意义（P〉0.05）。结论PON2基因多态性可能与中国湖南汉族人群脑卒中发病无关,C/S、G/A等位基因可能不是中国湖南地区汉族人群脑卒中发病的独立危险因素。Objective To study the relationship between single nucleotide polymorphisms of paraoxonase 2 （PON2） and stroke. Melhods Objects examined comprised of three groups： 120 healthy people, 150 patients with cerebral hemorrhage, 180 patients with cerebral infarction, ThePON2 genotypes were determined with PCR and digested by specific restriction enzymes. Results C311S and G148A polymorphisms of PON2 gene existed among population of Chinese Hunan area, with the allele frequencies 0.23/0.77 for C/S and 0.57/0.43 for G/A in the control group. There was no significant difference of genotype and allele frequency between stroke patients and controls （P 〉 0.05）. Conclusion C311S polymorphism of PON2 has no significant correlation with stroke in Han people of Chinese Hunan area and allele C/S isn＇t an independent risk factor for stroke, neither is G148A.

关 键 词：脑出血 脑梗死 对氧磷酶2 遗传多态性 

分 类 号：R686[医药卫生—骨科学]