NT-proBNP的检测在急性心肌梗死中的应用  

Assay of NT-proBNP in acute myocardial infarction

作　　者：陈国敏[1] 李旭东[1] 唐修明[1] 

机构地区：[1]广东东莞市太平人民医院,广东东莞523900

出　　处：《实用心脑肺血管病杂志》2007年第5期340-342,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨N末端B型脑钠尿肽(NT-proBNP)在急性心肌梗死(AMI)患者的临床应用价值。方法应用电化学发光法检测急性ST段抬高型心肌梗塞患者53例血中NT-proBNP的水平变化,分析其与心功能分级的关系。对照组为健康体检者24例,均已排除心、脑血管疾病。结果急性ST段抬高型心肌梗塞患者血中NT-proBNP水平显著高于正常心功能对照组(P<0.01)。患病组心功能≥Ⅱ级组血NT-proBNP显著高于心功能Ⅰ级组,心功能Ⅰ～Ⅳ级患者组各组间血清NT-proBNP水平差异均有统计学意义(P<0.01),随着心功能级数递增,NT-proBNP水平增高。NT-proBNP与Killip分级呈正相关。结论AMI后心脏钠尿肽系统激活,其改变与心功能损伤程度有关,因此NT-proBNP的测定可为临床诊断提供依据。Objective To observe the diagnostic significance on change of NT-pro BNP in acute myocardial infarction （AMI）. Methods The change of serum NT-pro BNP was examined in 53 patients with AMI by use of electrochemistry luminescence and other 24 healthy persons as the control. And last the relationship was analysed between the level of serum NT-pro BNP and the serious degree of cardiac function. Results The level of serum NT-pro BNP was signicantly higher than normal control（P〉0.01）, and the change of level was concerned with the serious degree of cardiac functiori（Killip classification）. Conclusion A signicant correlation existed between the level of serum NT-pro BNP and the serious degree of cardiac insufficiency （Killip classification）, so we could act as an indication of cardiac function in the cases of AMI with a rise of ST segment.

关 键 词：急性心肌梗死 NT-PROBNP 心脏功能 

分 类 号：R543.3[医药卫生—心血管疾病]