神经束内微电极记录家兔心电信号的实验研究  

Experimental Study on the Electrical Signals of Cardiac Sympathetic Nerve Recorded by Intrafascicular Microelectrodes in Rabbits

作　　者：王月兰[1] 蔡荣林[1] 周逸平[1] 汪克明[1] 胡玲[1] 吴子建[1] 陈业农[1] 唐晓敏[1] 李晓民[1] 李姿慧[1] 

机构地区：[1]安徽中医学院经脉脏腑相关研究中心,安徽合肥230038

出　　处：《安徽中医学院学报》2007年第3期24-27,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：国家重点基础研究发展计划973项目(2005CB523306;2005CB523308)

摘　　要：目的:采用神经束内微电极记录家兔心交感神经电信号,探讨不同状态下家兔心交感神经束内的电活动。方法:将特制铂铱合金微电极在16倍手术显微镜下植入心交感神经束内,用Biopac生物信号采集系统记录神经电信号,同时接入SKY-A4生物信号处理系统进行统计分析。比较正常状态下与心肌缺血时家兔心交感神经电信号的变化。结果:心交感神经电信号可持续记录,心肌缺血时心交感神经放电较正常时明显增强(P<0.01),微电极记录能很好反映神经束内电活动的变化。结论:神经束内微电极可稳定记录心交感神经电信号,能较好反映神经束内电活动的变化。Objective： To record the electrical signals of cardiac sympathetic nerve by microelectrode in rabbits, and compare the electrical signals in different conditions. Methods： Special microelectrode was insert directly under operating microscope by 16 X magnification into the fascicle of the cardiac sympathetic nerve. The electron- eurographic sign^ls were recorded by Boipac system, and statistically analyzed by using SKY-A4 signal processing system. The electrical signals of cardiac sympathetic nerve while myocardial ischemia were compared with those in normal condition. Results： The electrical signals of cardiac sympathetic nerve could be record continually. The neural discharge of cardiac sympathetic nerve while myocardial ischemia was enhanced compared with that in normal condition （P 〈 0. 01 ）. The microelectrode recording could well reflect the changes of electric activity of the nerve tract. Conclusion： Intrafascicular microelectrodes can stably record the electrical signals of cardiac sympathetic nerve. It could well reflect the change of electric activity.

关 键 词：心交感神经 神经动作电位 神经束内微电极 交感神经系统 

分 类 号：R338[医药卫生—人体生理学]