急性心肌梗死患者外周血红蛋白含量白细胞及血脂变化的临床研究  

Changes of hemoglobin,leukocyte count and blood lipid in patients with acute myocardial infarction

作　　者：魏玲[1] 杨丽霞[1] 齐峰[1] 郭传明[1] 王先梅[1] 石燕昆[1] 王燕[1] 任丽[1] 李俐丽[1] 

机构地区：[1]成都军区昆明总医院心血管内科,云南昆明650032

出　　处：《西南国防医药》2007年第3期297-300,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:探讨急性心肌梗死(AMI)患者外周血红蛋白含量、白细胞计数及血脂变化的临床意义。方法:对113例AMI患者应用美国库尔特JT血球计数器测定血红蛋白(Hb)含量、白细胞(WBC)数、中性粒细胞百分率(N%)、中性粒细胞绝对值(N)、淋巴细胞百分率(L%)、淋巴细胞绝对值(L)及血脂含量,结合冠状动脉造影(冠脉造影)及超声心动图检查,观察Hb含量、WBC数及血脂水平与冠状动脉硬化、AMI的相关性。结果:AMI患者外周血中Hb含量较正常对照组及心绞痛(AP)组显著增加(P<0.05)。四分位法研究AMI组Hb含量位于最高1/4位者较最低1/4位者显著增加(P<0.05)。AMI组Hb含量位于最高1/4位者较AP组显著增加(P<0.05)。Hb含量位于最高1/4位者发生AMI者较Hb含量位于最低1/4位者显著增加(P<0.05);AMI组WBC、N%、N、M%、M较正常对照组及心绞痛(AP)组显著增加(P<0.05),L较正常对照组显著降低(P<0.05);AMI组TG正常而对照组显著增加(P<0.05),AMI组TC≥5.72 mmol/L者占16.46%,TC>5.2 mmol/L者占31.3%;TG≥1.7 mmol/L者占46.34%;LDL≥3.12 mmol/L者占11.25%;HDL<0.91 mmol/L者占6.25%;总的血脂异常率为80.3%。但AMI及AP两组间血脂各项指标无显著性差异。冠状动脉造影显示AMI组冠状动脉狭窄≥95%及冠状动脉闭塞病变的发生率显著高于AP组,冠状动脉闭塞组Hb含量(150.92±13.11)g/L显著高于无冠状动脉闭塞组(139.98±13.11)g/L(P<0.05)。而冠状动脉闭塞组与冠状动脉非闭塞组之间血脂含量无显著性差异。结论:白细胞计数及血红蛋白含量均与AMI有关,其中血红蛋白还与冠脉狭窄冠脉闭塞有关。血红蛋白增高应作为AMI的危险因子受到重视。Objective：;To investigate the changes of hemoglobin（Hb）, leukocyte count （WBC） and blood lipid in patients with acute myocardial infarction（AMI）. 113 senile AMI patients were enrolled in this study. The levels of their hematologic and biochemical indexes, including Hb, WBC and blood lipid were examined. At the same time, they were performed the coronary arteriography and echocardiography. The relationship among Hb, WBC, serum and atherosclerosis and AMI were analyzed. Results. The levels of Hb and WBC of AMI group were higher than those of normal group and angina pectoris（AP） group（P〈0. 05）. The plasma triglyceride（TG） increased in AMI group compared with the normal group（P〈0.05）. In AMI group, the abnormal rates of total cholesterol, TG, lowdensity lipoprotein and high - density lipoprotein were 16.46%, 46. 34%, 11.25% and 6. 25%, respectively, and the total abnormal rate of blood lipid was 80. 3%. Between AMI group and AP group, there was not significant difference of blood lipid indexes. The coronary arteriography indicated that the incidence of coronary artery stenosis≥95% or coronary artery occlusion of AMI group was higher than that of AP group（P〈0.05）. The level of Hb in the patients with coronary artery occlusion was higher than that without coronary artery occlusion. Conclusion： Hb, WBC and blood lipid are concerned with elevation of .FLMI risk and Hb iner.easing should be noticed as a risk of AMI.

关 键 词：血红蛋白 血粘度 白细胞 血脂 急性心肌梗死 冠状动脉造影 冠状动脉狭窄 

分 类 号：R54[医药卫生—心血管疾病]