肺癌患者乙酰化代谢基因型探讨  

Relationship between genetic polymorphisms of N-acetyltransferase 2 and lung cancer

作　　者：高建平[1] 杨国宗[1] 郑家祥[1] 梁建平[1] 林经安[2] 方晓霞[3] 

机构地区：[1]福建省漳州市中医院,363000 [2]福建医科大学附属第一医院 [3]福建省龙岩市第一医院

出　　处：《检验医学与临床》2007年第6期480-481,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨N-乙酰基转移酶2(NAT2)基因多态性与肺癌易感性的关系。方法应用自动实时荧光Light-Cycler技术,分析138例肺癌患者和112例健康人NAT24个位点的基因多态性,比较肺癌患者与对照组间频率差异。结果肺癌组(吸烟者)NAT2慢乙酰化基因型频率与对照组比较差异有统计学意义(χ2=7.97,P<0.05),并使患肺癌的危险度提高了3.12倍(P<0.05);肺癌组(非吸烟者)NAT2慢乙酰化基因型频率与对照组比较差异无统计学意义(χ2=2.88,P>0.05)。结论携带NAT2慢乙酰化基因型的吸烟者可能是肺癌的高危人群。Objective To study the possible relationship between N-acetyltransferase 2 （NAT2） genetic polymorphisms and susceptibility of lung cancer. Methods NAT2 genetic polymorphisms in 138 cases of patients with lung cancer and 112 healthy controls were analyzed with real-time fluorescence Light-Cycler assay. The difference of frequency was compared between lung cancer group and the control group. Results The significant differences was found between the controls and the lung cancer patients who were smokers in slow acetylation genotype frequency （x^2 =7.97,P〈0.05）. It increased the risk for lung cancer for 3. 12 times （P〈0. 05）. No significant difference was found between the controls and lung cancer patients who were non-smokers in slow acetylation genotype frequency （x^2 =2.88,P〉0.05）. Conclusion The smokers with slow acetylation genotype of N-acetyltransferase 2 might be people with high risk for occurrence of lung cancer.

关 键 词：N-乙酰基转移酶基因 肺癌 实时荧光检测 

分 类 号：R446.1[医药卫生—诊断学]