75例胎膜早破患者阴道液FFN与绒毛膜羊膜炎的临床分析  

The relationship between fetal fibronectin and chorionitis of premature rupture of membranes

作　　者：崔雪芳[1] 娄建英 

机构地区：[1]中山市陈星海医院妇产科,广东528415

出　　处：《中国优生与遗传杂志》2007年第6期79-80,共2页Chinese Journal of Birth Health & Heredity

基　　金：中山市医学科学技术研究基金(项目编号:2006A022)

摘　　要：目的通过检测胎膜早破患者中的胎儿纤连蛋白(FFN),探讨其与绒毛膜羊膜炎的关系,为预测胎膜早破中绒毛膜羊膜炎的发生提供较灵敏的检测方法。方法采用固相免疫吸附法对胎膜早破患者75例,健康孕妇50例进行血清C-反应蛋白定量检测、阴道液FFN定性检测,分娩后胎盘胎膜行病理检查。结果研究组CRP阳性率为37.33%,对照组为2%;FFN阳性率为85.33%,对照组为4%,差异有显著性(P<0.01)。研究组中FFN阳性者绒毛膜羊膜炎发生率明显高于阴性者,敏感性及特异性分别高达93.02%、75.00%,差异亦有显著性(P<0.01)。结论FFN与绒毛膜羊膜炎关系密切,可用于胎膜早破中预测绒毛膜羊膜炎的发生。Objective： To study the relationship between fetal fibronectin and chorionmmionitis. Methods： CRP and FFN were measured in samples of carivcal secretion from 75 women with premature rupture of membranes （PROM） and HematoxylinEosin （HE） staining of placenta were taken after delivery. 50 normal pregnant women took these tests too. Results： Positive rate of FFN in pregnant women with PROM and incidence of chorionmmionitis in FFN positive cases were higher than those in contral group. Conclusion： FFN is a significant marker to forecast chorionmmionitis of PROM.

关 键 词：胎儿纤维连接蛋白 绒毛膜羊膜炎 胎膜早破 

分 类 号：R714.433[医药卫生—妇产科学]