α-干扰素联合中药方剂治疗慢性乙型肝炎的临床研究  

Clinical study on combined treatment with Chinese herbal medicine and interferon-α inpatients with chronic hepatitis B

作　　者：黎义锦[1] 梁少兵 吴春晓 周轶 李岚生[1] 宋含平 

机构地区：[1]暨南大学医学院附属珠海市人民医院肝病中心,广东省珠海市519000

出　　处：《实用肝脏病杂志》2007年第3期163-164,151,共3页Journal of Practical Hepatology

摘　　要：目的研究α-干扰素联合中药方剂治疗慢性乙型肝炎的临床疗效及其机理。方法选择慢性乙型肝炎患者134例,分别给予α-干扰素联合中药方剂或单用治疗6个月,观察患者治疗前后肝功能、乙型肝炎病毒标志物的变化情况。结果在肝功能复常方面,治疗组优于两对照组,但无统计学差异(P>0.05);在HBeAg、HBV DNA阴转方面,治疗组明显优于两对照组,差异有统计学意义(P<0.01或0.05)。结论α-干扰素联合中药方剂治疗慢性乙型肝炎具有较好疗效,中药方剂能明显提高α-干扰素的抗病毒效果。Objective To study the clinical curative effect of combined treatment with Chinese herbal medicine and interferon-a in patients with chronic hepatitis B. Methods The patients in combined treatment group were treated with Chinese herbal medicine and interferon-a, while patients in group A and B treated only by Chinese herbal medicine or interferon -a, respectively, for 6 months; The liver function tests and hepatitis B virus markers were observed. Results There was no statistical difference with respect to liver function test normalization among combined, A and B group; but HBeAg and HBV DNA negativity in combined treated group was clearly superior to contrast groups A and B （ P〈0.01 or 0.05）. Conclusion It is good therapeutic method that combined treatment with Chinese herbal medicine and interferon -a in patients with chronic hepatitis B.

关 键 词：慢性乙型肝炎 A-干扰素 中药方剂 治疗 

分 类 号：R512.6[医药卫生—内科学]