雷尼镍催化氢化法制备吲哚-2-甲酸  

Synthesis of Indole-2-carboxylic Acid by Raney Ni Catalytic Hydrogenation

作　　者：薛勇[1] 方明海[1] 周文[2] 吾买尔江.吾斯曼 

机构地区：[1]解放军防化指挥工程学院化学系,北京102205 [2]解放军防化研究院科技处,北京102203 [3]塔里木油建公司安全科,新疆库尔勒841000

出　　处：《精细化工》2007年第6期571-572,共2页Fine Chemicals

摘　　要：以邻硝基甲苯和草酸二乙酯为起始原料，合成邻硝基苯丙酮酸乙酯的乙醇碱性溶液，再用雷尼镍催化剂，在60～70℃、1．5MPa压力下，用催化氢化法合成了吲哚-2-甲酸，总收率为70％（以邻硝基甲苯计算），用熔点、NMR、GC—MS谱图表征了该化合物。雷尼镍催化氢化方法合成吲哚-2-甲酸成本较低、后处理简单、无环境污染。The title compound was synthesized from o-nitrotoluene and diethyl oxalate as starting materials by catalytic hydrogenation of the intermediate ethyl o-nitrophenylpyruvate in the presence of Raney Ni at 60 -70 ℃ under 1.5 MPa pressure. The overall yield is 70% （based on o-nitrotoluene）. Structure of the compound was characterized by GC - MS and NMR spectrometry. This method of preparation is more economic than other methods, without environmental pollution.

关 键 词：邻硝基甲苯 吲哚-2-甲酸 草酸二乙酯 雷尼镍 催化氢化 

分 类 号：TQ225.12[化学工程—有机化工]