苯丙胺类气相色谱分析前衍生化条件筛选  

The derivatization conditions of amphetamines by GC/FID

作　　者：侯俊红[1] 廖林川[1] 颜有仪[1] 杨林[1] 陈渝[1] 付强[1] 

机构地区：[1]四川大学基础医学与法医学院,成都610041

出　　处：《刑事技术》2007年第3期6-8,共3页Forensic Science and Technology

基　　金：国家自然科学基金资助项目(30371577)

摘　　要：目的筛选适合于苯丙胺类气相色谱分析的衍生化试剂,同时寻找最佳衍生化条件。方法选择乙酸酐、三氟乙酸酐、3,5-二硝基苯甲酰氯3种衍生化试剂,以气相色谱作为检测方法,比较在不同的衍生条件下(加热方式、微波功率、时间等)的衍生效果。结果获得3种不同衍生化产物的气相色谱分析结果,得出苯丙胺类经乙酸酐乙酰化,于微波Ⅱ档衍生反应3min,衍生化反应完全满意的结果。结论在适当条件下选用乙酸酐对苯丙胺类进行完全的衍生化反应,适用于该类毒品的定量分析。Objective To investigate the conditions of derivatization and to get a better derivative reagents of Amphetamines. Method Three derivative reagents such as acetic anhydride, trifluoroacetic anhydride chloride and 3,5-dinitro-benmylchloride were selected, the derivatization conditions and results were investigated and compared by using GC. Result Qualitative and quantitative analysis conditions to this kind of drugs after acetic acetylation were setup. Conclusion The regulation to the products and some quantitative parameters after derivatization by GC/FID were determined.

关 键 词：苯丙胺 微波衍生 乙酸酐 三氟乙酸酐 3 5-二硝基苯甲酰氯 

分 类 号：D919.2[医药卫生—法医学]