可乐定对术后恢复室患者的影响  

The study of clonidine on the patients in PACU

作　　者：李传刚[1] 张炳熙[1] 年阿兴[1] 林红[1] 黄红梅[1] 宋艳淳[1] 

机构地区：[1]首都医科大学附属北京同仁医院麻醉科,北京100730

出　　处：《中国耳鼻咽喉头颈外科》2007年第2期116-118,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的研究可乐定对术后恢复室患者血流动力学及血浆儿茶酚胺的影响。方法28例择期改良悬雍垂腭咽成形术并留置气管导管入术后恢复室过夜观察的重症阻塞性睡眠呼吸暂停低通气综合征患者28例,随机分为两组,两组患者采用相同方案镇痛镇静治疗,可乐定组14例,入恢复室后预先缓慢静脉注射3μg/kg可乐定,对照组14例,无预先处理。当出现血压增高和/或心率增快,以血管活性药物进行调整。观察两组血流动力学改变,并记录血管活性药物的用量。分别于术前、入恢复室两小时、出恢复室前采集动脉血测定并比较两组血浆儿茶酚胺水平。结果可乐定组血流动力学较对照组明显稳定,血管活性药物用量明显少于对照组(P<0.05)。入恢复室两小时及出恢复室前可乐定组病例血浆儿茶酚胺水平明显低于对照组(P<0.05)。结论可乐定用于恢复室控制血流动力学变化效果较好,并能降低患者应激激素的水平,利于患者术后的恢复。OBJECTIVE To study the influence of clonidine on the hemadynamics and plasma catecholamine of the postoperative patients in PACU. METHODS Twenty eight patients suffered from severe OSAHS who underwent modified UPPP and monitored in the PACU after operation were divided randomly into two groups： clonidine group and control group. Both group received the same protocol of sedation and analgesia. Patients in clonidine group received clonidine 3ug/kg injected slowly when entered the PACU, and patients in control group received same volume of NS. Esmolol and Nitroglycerin were used to adjust the hemadynamics. The changing of hemadynamics was recorded, blood samples were taken before operation, 2 hours after entering PACU, before discharge from PACU to determine the changing of plasma catecholamine. RESULTS The hemadynamics was more stable in clonidine group than that in control group and less vasoactive agents were needed. The plasma catecholamine was much lower in clonidine group 2 hours after entering PACU and before discharge from PACU than that in control group. CONCLUSION Clonidine could be administered to stabilize the hemadinamics, to lower the level of stress hormone and could improve the recovery of the patients.

关 键 词：可乐定 儿茶酚胺类 低血压 悬雍垂腭咽成 形术 

分 类 号：R766[医药卫生—耳鼻咽喉科]