仿生浸泡对碳酸根掺杂的钙磷生物陶瓷表面的影响  

Influence of Biomimetic Immersion on the Surface of the Calcium Phosphate Bioceramics Containing the Carbonate

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作  者:卢晓英[1] 何永洋[1] 刘治[1] 翁杰[1] 

机构地区:[1]西南交通大学材料学院材料先进技术教育部重点实验室,成都610031

出  处:《中国生物医学工程学报》2007年第3期462-467,共6页Chinese Journal of Biomedical Engineering

基  金:国家重点基础研究项目(973G1999064760)。

摘  要:钙磷生物陶瓷表面类骨磷灰石层的形成对其诱导新骨生成起非常重要的作用。为了研究碳酸根掺杂的钙磷生物陶瓷其表面类骨磷灰石层形成的能力,利用体外模拟装置首次研究了碳酸根掺杂的钙磷生物陶瓷材料在仿生浸泡的过程其表面的类骨磷灰石层形成的变化。结果表明,钙磷生物陶瓷因有CO32-的存在,导致该材料形成类骨磷灰石晶体的时间大大提前。并且在-βTCP含量较低的相组成下(HA/-βTCP之比为9/1),该陶瓷在与模拟体液(SBF)作用较短的时间内(约9d)就能形成类骨磷灰石晶体。而不含CO32-的钙磷生物陶瓷却只能与SBF液作用较长时间(约14d)才开始形成类骨磷灰石晶体。在相同的作用时间内,含CO32-的钙磷生物陶瓷所形成的类骨磷灰石晶体的情况远远优于不含CO32-的钙磷生物陶瓷。此外,还有部分的缺钙羟基磷灰石晶体的形成。钙磷生物陶瓷中CO32-的掺杂引入,有利于该材料生物活性的提高,进而有利于骨缺损的快速修复。It has been deeply believed that the formation of the bone-like apatite in the calcium phosphate bioceramics is important to the growth of the new bone and the osteoinductivity of the materials. The aim of this study is to investigate the influence of carbonate mingling into calcium phosphate ceramics on the ability of formation the bone-like apatite. In this paper, the biomimetic immersion devices in vitro were employed to study the effect of the carbonate on the formation of the bone-like apatite in the calcium phosphate bioceramics in detail. The'results showed that the bone-like apatite and calcium-deficiented hydroxyapatite could be formed in shorter time for the carbonate mingling in this bioceramics. The results also showed that under the same phase composition ( HA/β-TCP = 9/1 ) circumstance, the carbonate-contained bioceramics could form the bone-like apatite in 9-day immersion time, while the noncarbonat-caontained ceramics could form the bone-like apatite in 14-day immersion time. And the formation of the bone-like apatite was superior in the carbonate-contained bioceramics to the noncarbonate-contained bioceramics in the same immersion days. Introducing the carbonate into the calcium phosphate bioceramics is good to improving the osteoinductivity of this bioceramics, which is great help to the restoration of the bone defect.

关 键 词:CO3^2- 钙磷陶瓷 类骨磷灰石 

分 类 号:R318[医药卫生—生物医学工程]

 

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