聚天冬氨酸衍生物在药物控释及组织工程领域中的应用(英文)  

Application of polyaspartate derivatives in drug delivery systems and tissue engineering

作　　者：赵彦生[1] 闫丰文[1] 刘永梅[1] 弭勇[1] 

机构地区：[1]太原理工大学化学化工学院,山西省太原市030024

出　　处：《中国组织工程研究与临床康复》2007年第18期3657-3660,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：山西省自然科学基金(20051021);山西省科技攻关项目(2006031104-03)~~

摘　　要：目的:综合分析聚天冬氨酸衍生物作为药物控释体系的制备方法。资料来源:应用计算机检索Elselvier,ACS publications,Springerlink 1990-01/2006-01有关聚天冬氨酸衍生物在药物控释及组织工程领域的文献,检索词“polyaspart*,hydrogels,micelles,complexes”,限定文章语言种类为English。同时检索中国学术期刊数据库1995-01/2006-01有关聚天冬氨酸衍生物在药物控释及组织工程领域的文献,检索词“天冬酰胺,结合物,凝胶,释放”,限定文章语言种类为中文。资料选择:对检索到的相关信息进行整理,选取针对性强的文章。同一领域的文献则选择近期发表或权威杂志的文章。资料提炼:共检索到56篇相关文献,其中29篇文章符合要求。资料综合:聚天冬氨酸衍生物是一种可生物降解并具有生物相容性的新材料。聚天冬氨酸衍生物药物缓释体系主要有共价复合大分子药物、微凝胶、微胶束等形式,它们具有较好的生物相容性和明显的控释效果。结论:聚天冬氨酸衍生物的合成路线短、操作简单,产物收率高,生物相容性好,具有较好的亲水性,易于同其他化合物反应进行修饰。积极研究聚天冬氨酸衍生物降解速率的影响因素,并寻求新的修饰手段来提高其作为药物控释体系的可控性,其在药物传输领域会有更广泛的应用。OBJECTIVE： To discuss the preparation methods of polyaspartate derivatives as drug delivery systems DATA SOURCES： An online search of Elselvier, ACS publications and Springedink between January 1990 and January 2006 was undertaken by using the keywords of ＂polyaspart＊, hydrogels, micelles, complexes＂ to identify the relevant articles published in English. Meanwhile, Chinese joumals full-text database ware scanned with computer to search relevant articles published from January 1995 to October 2005, and the keywords were ＂asparmide, complexes, hydrogels, release＂ with language limited to Chinese. STUDY SELECTION： All the related data ware analyzed to select those ware aimed directly at the criteria. As for the arU des in the same field, those published recently or published in the authority joumals ware preferred. DATA EXTRACTION： A total of 56 articles about the preparation methods of polyaspartate systems ware collected, and 29 of them ware in accordance with the inclusion criteria. DATA SYNTHESIS： Polyaspartate derivatives are new biodegradable and biocompatible materials. Covalent complexes, hydrogels and micelles, three main drug delivery systems of polyaspartate derivatives, exhibit good biocompatibility and conspicuous effect of control-release. CONCLUSION： With the help of the short synthesis route, simple manipulation, high production rate, the excellent biocompatibility as well as the better hydrophile, the polyaspartate derivatives are prone to reacting with other compounds for the modification. It is noted that the controllability of the control-release systems will be well improved through the researches of the influence factors of the degrading velocity and the new modifying method, additionally, the polyaspartate derivatives will be applied in the drug delivery field widely.

关 键 词：天冬氨酸/类似物和衍生物 水凝胶 迟效制剂 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]