吲唑的简便合成  

Simple synthesis of indazole

作　　者：蔡可迎[1] 宗志敏[1] 魏贤勇[1] 

机构地区：[1]中国矿业大学化工学院,江苏徐州221008

出　　处：《化学试剂》2007年第1期53-54,共2页Chemical Reagents

基　　金：江苏省高新技术产业发展项目(JHB05-33)

摘　　要：以邻硝基甲苯为原料,在乙醇钠催化下与草酸二乙酯缩合,然后经水解、双氧水氧化、盐酸酸化得到邻硝基苯乙酸,收率62%。邻硝基苯乙酸用8%硫化铵溶液在回流温度下还原2 h后再进行重氮化反应,将得到的重氮盐溶液于室温放置24 h得到吲唑,收率71%。两步总收率44%。o-Nitrophenylacetic acid was synthesized by condensation of o-nitrotoluene with diethyl oxalate catalyzed by＇C2H5ONa, followed by hydrolysis, oxidation with H2O2 and acidification with HCl, resulting in an approximate 62% yield. Indazole was synthesized in 71% yield by keeping the diazonation solution for 24 h at room temperature, which was prepared from reducing o-nitrophenylacetic acid with 8% （NH4）2S solution upon refluxing for 2 h and diazotizing with HCl and NaNO2. The overall yield was around 44 %.

关 键 词：吲唑 邻硝基苯乙酸 合成 

分 类 号：O626[理学—有机化学]