2,3,4,6-四乙酰基-β-D-吡喃葡萄糖基异硫氰酸酯的合成及在液相色谱中的应用  

The synthesis of 2,3,4,6-tetra-acetyl-(β-D-glycosyl)isothio-cyanate and application in liquid chromatography

作　　者：邓小娟[1] 周维义[1] 李文斌[1] 

机构地区：[1]天津大学分析测试中心,天津300072

出　　处：《化学试剂》2007年第2期99-101,共3页Chemical Reagents

摘　　要：以葡萄糖为原料经过乙酰化、溴化、叠氮化、硫氰酸化4步反应合成了2,3,4,6-四乙酰基--βD-吡喃葡萄糖基异硫氰酸酯(GITC),用NMR对其进行了表征,初步探讨了其反应机理。该合成方法与传统方法相比,具有条件温和,操作简便,易于纯化等优点。以GITC做柱前手性衍生化试剂,在高效液相色谱(HPLC)上用C18柱成功分离了一些胺基类对映体。Using a-D-glucose as the starting material, the title compound, 2, 3, 4, 6-tetra-O-acetyl-（ β-D-glycosyl）-isothiocyanate （GITC）, was synthesized and characterized by NMR, with the possible reaction mechanism discussed. Compared with conventional methods,the present method has the advantages of convenience in operation, mild reaction condition, and readiness for purification. Using the GITC as the reagent for pre-column chiral derivatization, some amino enantiomers were successfully separated in the C18 column by reversed phase high performance liquid chromatography.

关 键 词：吡喃葡萄糖基异硫氰酸酯 合成 分离 高效液相色谱 

分 类 号：O623.76[理学—有机化学]