一种水溶性四氮唑盐的合成  

Synthesis of a water-soluble tetrazolium salt

作　　者：沈文广[1] 王明亮[1] 谷保祥[1] 

机构地区：[1]东南大学化学化工学院,江苏南京210096

出　　处：《化学试剂》2007年第2期107-108,共2页Chemical Reagents

摘　　要：报道了2,3-双(2-甲氧基-4-硝基-5-磺酸苯基)-5-(对氯苯胺羰基)-2H-四氮唑单钠盐的合成方法。对氯苯胺和丙二酸二乙酯经缩合胺化、水解制得丙二酸单酰对氯苯胺,再与3-氨基-4-甲氧基-6-硝基苯磺酸钠的重氮盐偶合制得甲,以次氯酸钠氧化得到目标产物,产物结构经UVI、R1、HNMR确证。The synthesis of 2, 3-bis （2-methoxy-4-nitro-5-sul- fophenyl）-5-[ （ 4＇-chlorophenylamino ） carbonyl ]-2H-tetrazolium monosodium inner salt, a new tetrazolium reagent, was reported. The new tetrazolium reagent was prepared by condensation of pchloroaniline with diethyl malonate followed by hydrolysis to give the intermediate monomalonyl p-chloroaniline, which was then subjected to coupling with 3-dizo-4-methoxy-6-nitrobenzenesulfonic acid followed by oxidation with sodium hypochlorite. The structure of the target product was verified by UV, IR, and ^1HNMR.

关 键 词：四氮唑 生物还原 水溶性 合成 

分 类 号：O626.28[理学—有机化学]