Toll样受体、CD4^＋CD25^＋调节性T细胞与支气管哮喘的关系  

Relation between toll like receptor,CD4^＋ CD25^＋ regulatory T cell and bronchial asthma

作　　者：张倩[1] 殷凯生[1] 

机构地区：[1]南京医科大学第一附属医院呼吸科,210029

出　　处：《国际呼吸杂志》2007年第11期844-847,共4页International Journal of Respiration

基　　金：基金项目：国家自然科学基金青年科学基金项目（编号：30400191）;国家自然科学基金自由申请项目（编号：30570797）

摘　　要：Toll样受体（TLR）是机体识别环境中各种微生物的主要受体，是介导天然免疫和获得性免疫的桥梁。支气管哮喘（哮喘）的发病是环境和基因相互作用的结果，TLR与哮喘有着十分密切的关系。近年来，人们逐渐认识到Th1／Th2理论并不能充分阐明哮喘的发病机制。随着对哮喘的深入研究，CD4^＋CD25^＋调节性T细胞凸现其冰山一角。本文就近年来对TLR、CD4^＋CD25^＋调节性T细胞和哮喘关系的研究进展作一综述。The Toll like receptors（TLR） recognize self versus non-self molecular patterns and control several aspects of immunity and inflammation, including innate immune responses, antigen presentation, acquired immune responses, and most importantly cytokine gene expression. Asthma is a complex, heterogeneous disorder and gene-environment interaction is important in the aetiology of asthma. However, the pathogenesis of asthma could not be interpreted with Th1/Th2 paradigm sufficiently. Recently, the role of CD4^＋ CD25^＋ regulatory T cell in the development of asthma is closely focused on. This review will explore the relation between TLRs,CD4^＋ CD25^＋ regulatory T cell and asthma.

关 键 词：哮喘 TOLL样受体 CD4^+CD25^+调节性T细胞 单核苷酸多态性 

分 类 号：R5[医药卫生—内科学]